Role of BP1.3656 on Alcohol Responses

Status Completed

Clinical Trial Summary

The current study will determine whether a novel pharmacotherapy, BP1. 3656, affects laboratory alcohol self-administration in participants with alcohol use disorder (AUD).

Clinical Trial Description

The current study employs BP1.3656, a novel investigational compound with a track record for safety and tolerability in phase I clinical trials. When administered to mice, BP1.3656 was associated with increased metabolism of histamine and elevated brain dopamine and acetylcholine, suggestive of utility in psychiatric disorders including Alcohol Use Disorder (AUD). This study is a Phase II laboratory-based trial of BP1 .3656 for AUD. 40 non-treatment seeking participants with AUD will be recruited. Participants will be randomly assigned to intervention with BP1 .3656 or placebo in a within-subject, crossover design. During each intervention period, outcome measures relating to alcohol motivation and self-administration will be assessed in the laboratory. It is hypothesized that relative to placebo, alcohol self-administration will be decreased by BP1 .3656. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04727086
Study type	Interventional
Source	Centre for Addiction and Mental Health
Contact
Status	Completed
Phase	Phase 2
Start date	February 1, 2021
Completion date	August 31, 2022

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