Measuring the Neuroimmune Response to Alcohol

Status Completed

Clinical Trial Summary

This study uses positron emission tomography imaging of the 18-kDa translocator protein to measure the brain's immune response to alcohol.

Clinical Trial Description

Alcohol Use Disorder affects nearly 14% of the population, accruing considerable cost to individual families and society. Much of this cost stems from alcohol's influence on the immune system. Alcohol impairs peripheral immune function, evidenced by increased susceptibility to infection related diseases such as liver cirrhosis and pancreatitis. The neuroimmune consequences of alcohol are subtler. Preclinically, alcohol triggers neuroimmune abnormalities that contribute to cognitive dysfunction, neurodegeneration, and alter alcohol drinking behaviors. Yet, limited experimental tools hamper translational efforts to study alcohol's effects on neuroimmune function in people. We propose to address this deficit by developing an innovative human imaging paradigm that measures neuroimmune response to alcohol. ;

Study Design

Related Conditions & MeSH terms

Alcohol Drinking

Clinical Trial Details

NCT number	NCT04251221
Study type	Interventional
Source	Yale University
Contact
Status	Completed
Phase	Early Phase 1
Start date	June 20, 2019
Completion date	November 20, 2021

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05414344` - A Brief Intervention for Alcohol Users With Interpersonal Trauma	N/A
Completed	`NCT05521906` - Evaluation of PRYSHM for LGBTQIA2S+ Youth	N/A
Not yet recruiting	`NCT04786587` - Alcohol Self-reporting During Pregnancy. AUTOQUEST Study.
Withdrawn	`NCT04659278` - Endourage Complete Spectrum Oral Mucosal Drops (OMD) in Adults Desiring a Reduction in Ethanol Use	N/A
Not yet recruiting	`NCT03632408` - Hangover and Residual Zopiclone Effect on Spatial Perception	Phase 1
Completed	`NCT02718508` - An e-Parenting Skills Intervention to Decrease Injured Adolescents' Alcohol Use	N/A
Active, not recruiting	`NCT02629679` - Sports, Education and Consumption of Substances in Adolescents	N/A
Completed	`NCT02945371` - Tailored Inhibitory Control Training to Reverse EA-linked Deficits in Mid-life	N/A
Completed	`NCT01553136` - Varenicline Treatment of Alcohol Dependence in Smokers	Phase 2
Completed	`NCT01442753` - Family-Skills Training to Prevent Tobacco and Other Substance Use in Latino Youth	N/A
Completed	`NCT01081119` - Brief Voluntary Alcohol and Drug Intervention for Middle School Youth	Phase 2
Completed	`NCT00289965` - Substance Use Risk Education (SURE) Project	Phase 2
Completed	`NCT04510116` - Adults In The Making Prevention Trial	N/A
Completed	`NCT00506753` - Motivation and Skills for Delta-9-tetrahydrocannabinol/Ethanol (THC/ETOH+) Teens in Jail	N/A
Recruiting	`NCT05288790` - Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT	Phase 2
Recruiting	`NCT05620849` - Young Adult Education on Alcohol & Health	N/A
Recruiting	`NCT04054466` - Nursing Counseling to the Change of Behavior of Alcohol Consumption in Patients in HAART	N/A
Recruiting	`NCT03588754` - Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?	Phase 2
Recruiting	`NCT06074341` - TeleHealth Resources for IndiVidualizEd Goals (THRIVE) in Alcohol Recovery Study	N/A
Terminated	`NCT04596267` - Pitolisant Effects on Alcohol Self-Administration in Heavy Drinkers	Phase 1