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Topiramate's Effects on Heavy Drinking — TOPMRI  

Alcohol Drinking Clinical Trial

Official title:
Brain Mechanisms of Topiramate's Effects on Heavy Drinking

Clinical Trial Summary

The proposed project will utilize perfusion functional magnetic resonance imaging (fMRI) to examine the effects of topiramate on brain and behavioral responses in heavy drinkers to appetitive alcohol reminders (cues that motivate continued alcohol use and relapse). This project will yield novel findings on brain and behavioral responses to alcohol cues, the effects of topiramate on alcohol cue reactivity, and the mechanisms underlying topiramate's ability to blunt alcohol cue reactivity and heavy drinking.

Clinical Trial Description

This project is a double-blind, randomized, placebo-controlled study of topiramate's effects on brain and behavior responses in heavy drinkers. Eligible volunteers who meet study criteria will be randomized to receive either topiramate or placebo with weekly visits and medication management sessions. Participants will complete two magnetic resonance imaging sessions. The first scan session will occur prior to starting study drug, and the second scan will occur following six weeks of study drug. This project will yield novel findings on brain and behavioral responses to alcohol cues, the effects of topiramate on alcohol cue reactivity, and the mechanisms underlying topiramate's ability to blunt alcohol cue reactivity and heavy drinking. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02074904
Study type Interventional
Source University of Pennsylvania
Contact
Status Terminated
Phase Phase 2
Start date May 2015
Completion date March 2017
View Details
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