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Alcohol Drinking clinical trials

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NCT ID: NCT05731713 Recruiting - Alcohol Drinking Clinical Trials

Journey of Transformation Curriculum for Native American Youth

JOT
Start date: December 11, 2023
Phase: N/A
Study type: Interventional

The investigators will conduct a waitlist control trial to test the efficacy of the Journey of Transformation-Native Youth Health Leadership Program (JOT) in terms of delaying or reducing tobacco and other substance use and improving sexual health.

NCT ID: NCT05729256 Recruiting - Hiv Clinical Trials

Alcohol and "Heat of the Moment" Sexual Decision Making

Start date: November 1, 2023
Phase: N/A
Study type: Interventional

HIV transmission remains a significant public health concern, especially among men who have sex with men (MSM). Condomless anal intercourse (CAI) continues to be the major route of transmission for MSM. Thus, to reduce the incidence of HIV, it is critical to identify how contextual risk factors influence CAI and develop behavioral strategies that modify risk factors directly or reduce their influence on behavior. This study will examine the mechanisms through which one of the central contextual risk factors, heavy drinking, influences sexual decision processes in the natural environment and test the benefit of a brief intervention designed to reduce sexual risk behavior among those who engage in heavy drinking.

NCT ID: NCT05729243 Recruiting - Smoking Cessation Clinical Trials

Cytisine for Smoking Cessation

Start date: February 8, 2023
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to evaluate the safety and effectiveness of cytisine as a smoking cessation treatment in individuals with concurrent alcohol use disorder.

NCT ID: NCT05722483 Recruiting - Clinical trials for Alcohol Use Disorder

Intensive Virtual Treatment With Remote Abstinence Monitoring for Alcohol Use Disorder

Start date: January 30, 2023
Phase: N/A
Study type: Interventional

This single-arm pilot study will recruit participants with moderate to severe alcohol use disorder for a 4-week virtual intensive outpatient program (IOP). The program aims to replicate the structure and abstinence monitoring of a residential treatment program although the program is delivered entirely virtually.

NCT ID: NCT05712382 Not yet recruiting - Clinical trials for Alcohol Drinking in College

Promoting Maintenance of Change Following Brief Intervention for Alcohol Use

Start date: September 2025
Phase: N/A
Study type: Interventional

All students who enroll in the study will receive an efficacious counselor-delivered brief motivational intervention. The intervention is based in principles of motivational interviewing. Students complete a baseline assessment on their alcohol use and alcohol-related consequences. During the hour-long session, the counselor uses information from the baseline assessment to compare the student's level of alcohol consumption to that of peers at the same university, discuss choices that may lead to experiencing negative consequences, and provide opportunities for the student to set goals for risk reduction. This study will develop and pilot a maintenance enhancement intervention. The intervention is expected to consist of four components, for example: (1) Student participants may learn to use techniques based in mindfulness to cope with negative emotions. (2) Student participants may identify barriers to reducing their alcohol use and identify protective strategies for navigating those barriers. (3) Student participants may be presented with narratives from other students who successfully resumed moderate drinking after a heavy drinking episode. Students may also be prompted to identify alcohol free activities that they enjoy and can engage in after experiencing a heavy drinking episode. (4) Parents may also receive a handbook encouraging communication with their student about alcohol use.

NCT ID: NCT05709353 Recruiting - Clinical trials for Alcohol Use Disorder

MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress Disorder

MPATHY
Start date: September 19, 2023
Phase: Phase 2
Study type: Interventional

To explore the effectiveness of of MDMA-assisted prolonged exposure therapy in improving treatment outcomes for individuals with comorbid PTSD and alcohol use disorder in a double-blind randomised placebo-controlled trial.

NCT ID: NCT05692830 Recruiting - Alcohol Drinking Clinical Trials

Towards a Wearable Alcohol Biosensor: Examining the Accuracy of BAC Estimates From New-Generation Transdermal Technology Using Large-Scale Human Testing and Machine Learning Algorithms

Start date: April 3, 2022
Phase: N/A
Study type: Interventional

The study will employ a combined laboratory-ambulatory design. Participants will engage in ambulatory assessment over the course of 14 days, wearing biosensors assessing transdermal alcohol concentration (TAC) and providing breathalyzer readings in real-world contexts. Also during this period, participants will attend three laboratory alcohol-administration sessions scheduled at one-week intervals, with alcohol dose and rate of consumption manipulated within and between participants, respectively. Laboratory visits will also double as ambulatory orientation, check-in, and close-out sessions.

NCT ID: NCT05692271 Recruiting - Clinical trials for Alcohol Use Disorder

Testing a Novel Therapeutic Strategy for Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder

Start date: July 15, 2023
Phase: Phase 2
Study type: Interventional

This study evaluates the therapeutic tolerability of the use of Cognitive Processing Therapy (CPT) with propranolol in participants with Posttraumatic Stress Disorder (PTSD) and Alcohol Use Disorder (AUD). The investigators are planning to perform an initial proof -of- concept randomized, placebo- controlled trial evaluating propranolol in participants with PTSD and AUD starting CPT for 12 weeks with three post-treatment follow ups at week-16, week-20, and week-24. Participants with current diagnosis of PTSD and AUD seeking treatment will be randomized to either a propranolol group (n=24) or placebo group (n=24) after enrollment. All participants will receive CPT for 12 weeks after randomization. Primary outcomes will be measured in both groups at the end of the study (week 12).

NCT ID: NCT05689320 Not yet recruiting - Alcohol Drinking Clinical Trials

EMA_Normalization of Alcohol Drinking in Young Adults

Start date: January 2023
Phase: N/A
Study type: Interventional

This proposed study aims to evaluate incentive strategies on compliance rate of EMA, assess young adults' exposure to alcohol marketing, and its effect on receptivity outcomes, belief in normalization of alcohol drinking and alcohol consumption. The objectives are: 1. To compare the compliance rate of EMA between participants receiving one-off bonus and incremental incentive and receiving incremental incentive only. 2. To assess the association between exposure to alcohol marketing and drinking normalization, in terms of perceived popularity (descriptive norm), perceived social approval (injunctive norm) and positive expectancy. 3. To assess the association between exposure to alcohol marketing and alcohol consumption. 4. To assess the association between exposure frequency and receptivity to alcohol marketing. 5. To assess the association between receptivity to alcohol marketing and drinking normalization. 6. To assess the association between receptivity to alcohol marketing and alcohol consumption. 7. To explore factor structure of perceived popularity (descriptive norm), perceived social approval (injunctive norm) and positive expectancy. 8. To analyse drinking normalization effect in mediating the association between exposure to alcohol marketing, and alcohol consumption, and between receptivity and alcohol consumption.

NCT ID: NCT05684094 Recruiting - Clinical trials for Alcohol Use Disorder

Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep to Reward- and Stress-Related Brain Function

MoRA
Start date: September 7, 2023
Phase: N/A
Study type: Interventional

This research will use biobehavioral approaches to generate understanding about the linkages between stressful life events, sleep duration and timing, and alcohol use in young adults, with a long-term aim of developing effective preventative interventions for alcohol use disorders.