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The Efficacy and Neurobehavioural Mechanism of N-acetyl Cysteine (NAC) for Alcohol Dependence

Alcohol Dependence Clinical Trial

Official title:
The Efficacy and Neurobehavioural Mechanism of N-acetyl Cysteine for Alcohol Dependence: An Exploratory Pilot Study

Clinical Trial Summary

The study will explore the efficacy and tolerability of a regimen of NAC (2400 mg) versus placebo for the treatment of alcohol dependence.

Clinical Trial Description

Study 1: Relapse prevention: This is a double-blind, randomized, placebo-controlled clinical trial in which participants will receive oral NAC (2400 mg: 2x 600mg tablets twice per day) or matching placebo. Trial participants will receive either oral NAC ( dose stated above) or matching placebo for up to 4 weeks.

Study 2: Withdrawal: Trial participants will receive oral NAC (dose stated above) or matching placebo within the first 24 hours of their admission for up to 3 days.

Study 3: Participants from the relapse prevention substudy will also receive 30-minute non-invasive brain imaging session prior to and after completing the treatment regime in Study 1.

Both males and females will be recruited for the study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03879759
Study type Interventional
Source South West Sydney Local Health District
Contact Kirsten Morley, PhD
Phone +61295153636
Email kirsten.morley@sydney.edu.au
Status Recruiting
Phase Phase 2
Start date August 22, 2018
Completion date November 2020
View Details
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