Carisbamate as a Potential Treatment for Alcohol Dependence

Status Completed

Clinical Trial Summary

The purpose of this study is to determine the effects of treatment with carisbamate compared to treatment with placebo, on alcohol-induced stimulant and subjective effects in non-treatment seeking alcohol-dependent human volunteers.

Clinical Trial Description

This within-subjects placebo-controlled experimental protocol will assess the effects of carisbamate (600mg qd) on the positive subjective effects of alcohol in non-treatment-seeking alcohol-dependent volunteers. Participants will receive study drug (carisbamate or placebo) from days 2- 4. On day 4, study drug will be followed by alcohol (0.8g/kg; 16% by volume) and a placebo beverage (1% by volume as a mask), both separated by 2 hours. Physiologic, subjective effects and BAL will be obtained after the alcohol challenges. Participants will be discharged on day 4 and asked to return a week later to repeat the study under the alternate study drug condition (active carisbamate vs. placebo). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02435381
Study type	Interventional
Source	Baylor College of Medicine
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	February 2013
Completion date	September 30, 2013

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