Genetic and Neural Factors in Alcohol-Related Cognition

Alcohol Abuse Clinical Trial

Official title:

Genetic and Neural Factors in Alcohol-Related Cognition

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03725345
• Other study ID #: HM20013938
• Secondary ID: K01AA026647
• Status: Recruiting
• Phase: N/A
• Start date: July 11, 2023
• Est. completion date: June 2024

Study information

• Verified date: August 2023
• Source: Virginia Commonwealth University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study is about how genetic and brain factors impact cognitive processes and behavior after alcohol consumption. Participation in this project will contribute to a better understanding of biological factors that influence alcohol misuse. This study will be completed in two laboratory visits.

Description:

Some study details are purposely omitted at this time to preserve scientific integrity. Full details will be posted at the conclusion of the study.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 808
• Est. completion date: June 2024
• Est. primary completion date: June 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 21 Years to 45 Years

Eligibility

Inclusion Criteria:

• English speaking

• No current or regular use of prescribed or illicit psychoactive drugs

• Free of major health problems (e.g., diabetes, HIV, Parkinson's disease)

• Free of a neurological or psychiatric disorders

• No current drug abuse (e.g., recreational drug use).

• Right hand dominant

• Free of claustrophobia

• Free of pregnancy or suspected pregnancy

• Absent MRI risk factors (e.g., implanted medical device, body mass index > 35, braces)

• Free of medical conditions that render individuals with overly sensitive hearing

• Non-naive to alcohol consumption

Exclusion Criteria:

• Not meeting inclusion criteria listed above

Related Conditions & MeSH terms

• Alcohol Abuse
• Alcoholism

Intervention

Behavioral:
• MRI Scanner
Participants will enter the MRI scanner and complete a series of computer tasks that include noise blasts while undergoing brain scans that measure the structure and function of the brain

Locations

Country	Name	City	State
United States	Virginia Commonwealth University	Richmond	Virginia

Sponsors (2)

Lead Sponsor	Collaborator
Virginia Commonwealth University	National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in alcohol-influenced behavior	Competitive reaction-time behavior after recent consumption of an alcoholic beverages (versus without recent consumption of an alcoholic beverages) will be measured using the validated and computerized Taylor Competitive Reaction-Time Task. Some outcome measure details are purposely omitted at this time to preserve scientific integrity.	Approximately 7 days between alcohol consumption.