Alcohol Abuse Clinical Trial
Aggressive behavior, both in the form of violence toward others (injury-inflicting or
homicide) or toward oneself (suicide or self-injures) create problems of patient management,
treatment and paroles.
Biological causes of violent crime were hypothesized by Eysenck (1978), who believed that
criminality resulted from a nervous system distinct from that of most people.
The prefrontal cortex, regulates planning of motor acts and executive functions, which are
critical for inhibitory ability and control of impulsive outburst were found to be impaired
in violent subjects (Hoaken et al, 2003; Blair, 2001; Brower and Price, 2001; Filley et al,
2001; Raine et al, 2000; George et al, 2004; Dolan and Park, 2002; Stevens et al, 2003;
Raine and Yang, 2006), especially in impulsive offenders murderers (Raine et al, 1997;
1998). Violence act influenced by nonplaning outboards definite as impulsive aggression
(Linnoila and Charney, 1999), which one of the most important factor influenced by dangerous
behavior in general (for review: Skodol, 1998, Moeller et al, 2001; Pontius, 2000; 2004;
Siever, 2008).
Cholesterol and fats have many roles and may influence brain function and behavior through
modification of membranes; myelin; enzyme function; absorption and transport of fat-soluble
vitamins and toxins; and steroid hormones and through effects on production, reuptake, or
metabolism of neurotransmitters (Boston et al, 1996).
Since 80-th a strong association was found between low cholesterol levels and violent
behavior, an association that was not due to age, race, sex, or diagnosis (Mufti et al,
1998; New et al, 1999; Alvarez et al, 2000; Golomb et al, 2000; Hillbrand et al, 2000;
Troisi and D'Argenio, 2006; Chakrabarat and Sinha, 2006).
Associations between violent behavior, cognitive functioning and total cholesterol level
were contradicted with difference in samples and behavioral parameters: homicide, homicide
attempts, rape, physical or verbal aggression, complete suicide or suicide attempts, only
partially accounted for each measure of behaviors, suggesting that further investigation is
warranted. Because of the inconsistencies in the available data, we studied retrospectively
a group of criminal offenders with alcohol and drug use. Our analysis of lipid constituents
in serum focused on TC, HDL, LDL, and TG.
Significance of the study. It is possible that cholesterol profile is a biomarker and
potential predictor of violent in patients with polydrug use.
The purpose of this retrospective study is to investigate the correlations between
cholesterol and cognitive profiles in psychiatric patients with violent behaviour. The
demographic and criminal records, clinical characteristics, cholesterol profiles, and
cognitive performance data of these patients will be will be intercorrelated.
n/a
Time Perspective: Retrospective
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