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Alcohol Abstinence clinical trials

View clinical trials related to Alcohol Abstinence.

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NCT ID: NCT05778734 Recruiting - Clinical trials for Alcohol Use Disorder

StuDy AimED at Increasing AlCohol AbsTinEnce

Start date: July 30, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to test the feasibility & acceptability of an integrated CM-PST intervention (in K99 phase) and preliminary efficacy (in R00 phase), vs. CM alone, to improve treatment efficacy and inform about neural mechanisms of treatment effects in young adults with Alcohol Use Disorder (AUD). The aims are as follows: K99 Aim: Test feasibility & acceptability of a developed CM-PST, by meeting these benchmarks: 2a Feasibility: enroll 20 participants in the new CM-PST in a single-arm pre- and post-study, and retain ≥85% at wk 12. 2b Deliver CM-PST at ≥90% fidelity to intervention protocol. 2c Acceptability to participants: Achieve mean score ≥3 on Client Satisfaction Scale Questionnaire and satisfaction from semi-structured interviews. R00 Aim 1) Test preliminary efficacy of CM-PST in a 2-arm pilot RCT: Male/female young adults (aged18-24) who meet AUD criteria will be randomized to CM-PST or CM-only control, and assessed at baseline (0), 3, and 6 months. Primary study endpoint will be 3 months. R00 Aim 2 (Exploratory) Explore potential neural mechanisms of CM-PST effects, by fMRI scanning & analyses of core regions of the brain circuits regulating positive affect (ventral striatum), negative affect (amygdala), and cognitive control (dorsolateral prefrontal cortex), and connectivity between these core regions.

NCT ID: NCT05522075 Recruiting - Aging Clinical Trials

Reducing Blood Pressure in Mid-life Adult Binge Drinkers

Start date: November 21, 2022
Phase: N/A
Study type: Interventional

This study has two phases: Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers. Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers

NCT ID: NCT04659278 Withdrawn - Alcohol Drinking Clinical Trials

Endourage Complete Spectrum Oral Mucosal Drops (OMD) in Adults Desiring a Reduction in Ethanol Use

Start date: September 2021
Phase: N/A
Study type: Interventional

This is the first clinical trial of Endourage OMD 1200 for persons desiring to reduce their alcohol consumption.

NCT ID: NCT03521115 Completed - Alcohol Drinking Clinical Trials

Family Based Prevention of Alcohol and Risky Sex for Older Teens

Start date: April 1, 2013
Phase: N/A
Study type: Interventional

An online, interactive web-based program for older teens and their parents is designed to address teen alcohol use and teen relationships. The parent-teen dyad both participate in the web-based program and engage in off-line discussion activities. This intervention promotes communication skills, refusal skills, and helps teens consider how to make healthy choices. A total of 411 family dyads (one parent, one teen) were recruited.

NCT ID: NCT03287154 Recruiting - Clinical trials for Alcoholic Intoxication

Interest of tDCS in Help for Supporting Alcohol Abstinence

ITAMAA
Start date: February 8, 2017
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate in patients with alcohol disorder and forehand weaned the efficiency of 10 active tDCS sessions versus 10 sham (placebo) sessions in the support of abstinence at 3 months.

NCT ID: NCT03137082 Completed - Alcohol Abstinence Clinical Trials

Guanfacine to Reduce Relapse Risk in Women With Alcohol Use Disorder (AUD)

Start date: July 12, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

Guanfacine may preferentially reduce craving and improve cognitive control in women with Alcohol Use Disorder (AUD), compared to men. As these behaviors are related to relapse, the objectives of this study are to conduct a 10-week out-patient clinical trial to examine the effects of Guanfacine Extended Release (XR; 3mgs) versus placebo on drinking measures in women with AUD.

NCT ID: NCT03099590 Completed - Clinical trials for Alcohol Use Disorder

Alkontrol-herbal Effects on Alcohol Drinking

Alkontrol
Start date: January 1, 2018
Phase: Phase 2
Study type: Interventional

Participants will enroll in a 14-week study (2 weeks of baseline, 8 weeks of treatment, and 4 weeks of follow-up) investigating the impact that Alkontrol-herbal (Isoflavone; Kudzu) has on alcohol intake in a population seeking treatment for an alcohol use disorder.

NCT ID: NCT02071836 Completed - Heavy Drinking Clinical Trials

A Web Application to Reduce Heavy Drinking in First-time DWI Offenders

Start date: May 2014
Phase: N/A
Study type: Interventional

The overall objective of this project is to develop, evaluate, and disseminate a web application for first-time DWI offenders that will provide them with an age-appropriate brief motivational intervention (BMI) to motivate them to reduce their drinking and a cognitive behavioral intervention (CBI) for to help them achieve and maintain abstinence. The goal is to reduce heavy drinking and consequently the risk for future drunk driving. The specific objectives of this Phase II are: - Completing the development of the Right Turns prototype based on feedback from the Phase I pilot study participants. This includes: providing more structure and guidance as participants work in the Tool Box section of the program; simplifying the content of the Tool Box; further R&D in the text messaging feature for 2nd and 3rd tier cellular providers; implement a customized pdf report function for progress reports from the program to users' probation officers (under control of the user); developing a follow-up component and outcome reports; and revising the videos in the Tool Box to reflect greater diversity and a younger population of drinkers. - Conducting a randomized clinical trial of the program with first time DWI/DUI offenders who are recruited locally, collecting follow-up data, analyzing the data, and reporting the results.

NCT ID: NCT01307345 Completed - Alcohol Use Clinical Trials

Remote Monitoring and Contingency Management Reinforcement for Alcohol Abstinence

Start date: February 2011
Phase: N/A
Study type: Interventional

This pilot project proposes to monitor real-world alcohol use using a novel technology—cell phone videorecordings in conjunction with breathalyzer recordings—and to conduct a small randomized study of this technology for reinforcing alcohol abstinence. Individuals with frequent alcohol use (N = 30) will be asked to carry a study cell phone plus a handheld breathalyzer for one month. Participants will be randomized to one of two conditions: alcohol monitoring or alcohol monitoring plus contingency management. In both conditions, research assistants will telephone participants on their cell phone an average of 10 times per week to request submission of a breathalyzer sample using the video monitoring function on the cell phone. Samples will be time and date stamped, and the video containing the breathalyzer result will be sent to study staff via the cell phone. Participants will be compensated for each video recorded within one hour of receiving the prompt. Participants randomized to the contingency management condition will receive the same alcohol monitoring described above, and they will also receive reinforcement for each alcohol negative breath sample submitted within one hour of the prompt. Data from this pilot project will be useful for (1) determining the feasibility of assessing alcohol use in the natural environment via breathalyzers and cell phone technology, and (2) estimating effect sizes of a CM intervention that reinforces alcohol abstinence using breathalyzers and cell phone technology. In an exploratory manner, we will also evaluate the reliability and validity of the video monitoring procedure and trends toward changes in psychosocial functioning.

NCT ID: NCT00810901 Completed - Clinical trials for Tissue and Organ Procurement

Intervention to Motivate Teens to be a Designated Organ Donor on Driver's License

Idecide
Start date: April 2008
Phase: N/A
Study type: Interventional

This study will test the effectiveness of a multimedia campaign to educate ethnic minority teens about the choice to become a designated organ donor on their first driver's license.