AITd Patients With Different Polymorphisms Clinical Trial
Official title:
The Association of Costimulatory Molecules and PPAR-polymorphisms With Autoimmune Thyroid Disease in Taiwan
Autoimmune thyroid disease is the most common organ-specific autoimmune disease. AITD
include Graves' disease and Hashimoto's thyroiditis. Although the pathogenesis of AITD
remains unclear, it is generally thought that the mechanisms of the disease is a complex
disease in which susceptibility genes and environmental triggers act in concert to initiate
the autoimmune response to the thyroid.
The initial step of thyroid autoimmunity is the activation of T cells. The activation of T
cell requires two signals: firstly, thyroid follicular cells or antigen presenting cells
binds to T cell receptor through antigenic HLA complex. Secondly, the activation of T cells
is also required the interaction of costimulatory molecules between thyroid follicular cells
and immune cells, including CTLA-4, CD 40, CD28, ICOS. PPAR- is a kind of intranuclear
transcription factor, associated with adipogenesis and inflammation. Some reports showed
that PPAR- polymorphism may have a protective effect from Graves' ophthalmopathy.
The goal of the study is to investigate the relationship among SNP and mRNA of costimulatory
molecules and PPAR- , serum cytokine including TNF- and sIL-2R, and clinical characteristics
in AITD patients. From the study, we hope to clarify the role of costimulatory molecules and
PPAR- polymorphism in AITD.
Autoimmune thyroid disease is the most common organ-specific autoimmune disease. AITD
include Graves' disease and Hashimoto's thyroiditis. Although the pathogenesis of AITD
remains unclear, it is generally thought that the mechanisms of the disease is a complex
disease in which susceptibility genes and environmental triggers act in concert to initiate
the autoimmune response to the thyroid.
The initial step of thyroid autoimmunity is the activation of T cells. The activation of T
cell requires two signals: firstly, thyroid follicular cells or antigen presenting cells
binds to T cell receptor through antigenic HLA complex. Secondly, the activation of T cells
is also required the interaction of costimulatory molecules between thyroid follicular cells
and immune cells, including CTLA-4, CD 40, CD28, ICOS. PPAR- is a kind of intranuclear
transcription factor, associated with adipogenesis and inflammation. Some reports showed
that PPAR- polymorphism may have a protective effect from Graves' ophthalmopathy.
The goal of the study is to investigate the relationship among SNP and mRNA of costimulatory
molecules and PPAR- , serum cytokine including TNF- and sIL-2R, and clinical characteristics
in AITD patients. From the study, we hope to clarify the role of costimulatory molecules and
PPAR- polymorphism in AITD.
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Observational Model: Cohort, Time Perspective: Prospective