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Clinical Features and Airways Inflammation in Never Smokers and Smokers With COPD

COPD Clinical Trial

Official title:
Airway Inflammatory Profile and Clinical Presentation of COPD: A Comparison Between Never Smokers and Smokers

Clinical Trial Summary

The aim of this study was to investigate the airway inflammatory profile and the clinical presentation of chronic obstructive pulmonary disease (COPD) in never smokers compared to smokers with COPD.

Clinical Trial Description

40 COPD patients (21 smokers and 19 never smokers) and 28 healthy never smokers were included in the present study. Information about respiratory symptoms and comorbidities were collected. Subjects underwent pulmonary function tests and COPD was defined according to Global Initiative for Chronic Obstructive lung Disease spirometric criteria. Induced sputum was collected to determine total and differential inflammatory cells counts as well as inflammatory mediators (Interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α)). The Mann-Whitney U and the χ2 tests were used for results comparisons. Correlations between symptoms, spirometric parameters, cytokines levels, inflammatory cells and risk factors of COPD were examined with Spearman's rank correlation test. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03274791
Study type Observational
Source Ministry of Scientific Research, Tunisia
Contact
Status Completed
Phase N/A
Start date September 2013
Completion date January 2017
View Details
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