Airway Extubation Clinical Trial
Official title:
Maximum Expiratory Pressure in Induced Cough as a Predictor of Extubation Failure in Intensive Care Unit Patients on Mechanical Ventilation Ready to Extubate. A Single-arm Open Clinical Trial.
Clinical trial for the evaluation of diagnostic tests. The sample was composed of adults under mechanical ventilation who passed the spontaneous breathing trial and was ready to be extubated. The maximum expiratory pressure measured in the usual way and the maximum expiratory pressure generated during the induced cough were taken as predictor variables. The outcome variable was extubation failure, measured at 72 hours and at 7 days.
After completing the spontaneous breathing trial (SBT), with the extubation decision defined
by the physician in charge of the patient and maximal expiratory pressure (MEP) as usually
measured greater than 30 centimeters of water (cmH2O). Following this, the patient was
allowed to rest for 5 minutes in the same condition. With the patient in the supine position
sitting 45 ° to 60 °, the closed suction catheter was removed, an elbow was placed at 90 °
and a bacterial filter in series with the endotracheal tube (ET), an adapter was also coupled
with a outlet port to the aneroid pressure gauge. In series an inspiratory unidirectional
valve was placed that did not allow expiration. Immediately 2 ml of physiological solution
was slowly instilled through the port in the 90º elbow to trigger the cough reflex. The
presence or absence of reflex cough and the MEP during induced cough (MEPic) value were
verified.
As a safety method, the procedures were stopped if the patient presented signs of intolerance
such as respiratory rate (RF)> 35 breaths per minute, saturation <90%, heart rate (HR)> 140
beats per minute or increase of 20 % of resting levels.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05114551 -
ICU Predictive Score of WEaning Success in Patients At Risk of Extubation Failure
|
||
| Recruiting |
NCT06154811 -
Exploring the Use of Pulse Tissue Doppler in Predicting Extubation Success in Mechanically Ventilated Patients
|
||
| Recruiting |
NCT04708509 -
Extubation Advisor: Initial Implementation and Evaluation of a Novel Extubation Clinical Decision Support Tool
|
Phase 1 | |
| Recruiting |
NCT06110390 -
High-flow Nasal Oxygen Therapy to Prevent Extubation Failure in Adult Trauma Intensive Care Patients
|
N/A | |
| Not yet recruiting |
NCT05506904 -
Liberation From Mechanical Ventilation Using Extubation Advisor Decision Support
|
Phase 1 | |
| Recruiting |
NCT05999526 -
Mechanical Ventilation Reconnection for One Hour After Spontaneous Breathing Trial
|
N/A | |
| Completed |
NCT02799056 -
Diaphragmatic and Pulmonary US for Extubation Success Prediction
|
||
| Not yet recruiting |
NCT04266535 -
TCI vs Manually Controlled Infusion of Propofol
|
||
| Enrolling by invitation |
NCT05523479 -
The Maximizing Extubation Outcomes Through Educational and Organizational Research (METEOR) Trial
|
N/A | |
| Completed |
NCT01513772 -
The Effect of Dexmedetomidine on the Emergence Agitation in Nasal Surgery
|
N/A | |
| Completed |
NCT03495947 -
High Flow Nasal Cannula in Immediately Post Extubation
|
||
| Recruiting |
NCT03946371 -
Relation Between the Volume of Subglottic Secretion and Risk of Extubation Failure in ICU Patients (SEGEX)
|
||
| Recruiting |
NCT05356299 -
Analysis of the Magnetic Tape Bandage on Respiratory Functional Effects.
|
N/A |