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Electroconvulsive Therapy (ECT) for Agitation in Dementia (AD) — ECT-AD  

Alzheimer Dementia Clinical Trial

Official title:
Effect and Safety of Electroconvulsive Therapy Plus Usual Care for the Acute Management of Severe Agitation in Dementia

Clinical Trial Summary

This study will explore the effect of ECT treatments plus usual care (ECT+UC) in reducing severe agitation in patients with moderate to severe dementia including Alzheimer's Disease, Vascular dementia, Frontotemporal dementia, and Dementia with Lewy Bodies. The study will also determine the tolerability/safety outcomes of ECT+UC.

Clinical Trial Description

This study will be a single-arm, unblinded, non-randomized trial to determine the effect and safety of ECT for severe agitation in moderate to severe stage dementia, while also examining the durability of the acute treatment effect in an exploratory maintenance naturalistic design. We plan to enroll 50 participants with an estimated dropout rate of 20%. We expect 50 participants to complete at least 1 ECT treatment before moving into the 12-month naturalistic follow-up phase. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03926520
Study type Interventional
Source Mclean Hospital
Contact Jefferson Mattingly, BA
Phone 617-855-3168
Email jmattingly@mclean.harvard.edu
Status Recruiting
Phase N/A
Start date January 28, 2021
Completion date May 31, 2025
View Details
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