Age Related Macular Degeneration Clinical Trial
Official title:
Clinical Research of Photodynamic Therapy for Exudative Age-related Macular Degeneration Accompanied With Polypoidal Choroidal Vasculopathy
The purpose of this study is to evaluate and conduct an exploratory comparison of the efficacy and safety of indocyanine green angiography (ICGA) guided photodynamic therapy (PDT) and fluorescein angiography (FA) guided PDT for exudative age-related macular degeneration (AMD) accompanied with polypoidal choroidal vasculopathy (PCV).
PDT with verteporfin has been proven beneficial for patients with AMD. The laser spot size
is decided based on FA finding (FA guided PDT). ICGA is needed to detect PCV lesions, such
as polypoidal lesions or abnormal network vessels. In clinical practice, PDT based on ICGA
(ICGA guided PDT) has and is being conducted for the treatment of AMD with PCV. However,
there are no reports on the outcomes of prospective research of PDT for PCV in Japanese
patients. Furthermore, there are no reports comparing FA guided PDT and ICGA guided PDT.
We propose to conduct this clinical research in order to investigate the efficacy and safety
of PDT for PCV in Japanese patients, and to compare results of FA guided PDT and ICGA guided
PDT.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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