Decoding the Cognitive Trajectory of Hong Kong SuperAgers: a Longitudinal Follow-up Study

Age-related Cognitive Decline Clinical Trial

Official title:

Decoding the Cognitive Trajectory of Hong Kong SuperAgers: a Longitudinal Follow-up Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05728801
• Other study ID #: 2019.078
• Status: Recruiting
• Start date: June 1, 2022
• Est. completion date: December 1, 2024

Study information

• Verified date: December 2023
• Source: Chinese University of Hong Kong
• Contact: Hanna LU, PhD
• Phone: 85226076063
• Email: hannalu[@]cuhk.edu.hk
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This is a prospective follow-up study conducted at the Department of Psychiatry, The Chinese University of Hong Kong. The participants, including high-performing elderly (SuperAgers), normal ageing elderly and neurocognitive disorder (NCD) patients will be re-invited from our previous cohort (2013-2014) (N=488).

Description:

Objectives: This study aims to investigate the cognitive changes in older adults with different cognitive statuses.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 400
• Est. completion date: December 1, 2024
• Est. primary completion date: June 1, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 95 Years

Eligibility

Inclusion Criteria:

• SuperAgers are determined by the scores of global cognitive function. This ensured that the participants are divided by a measure relevant to the current study without directly biasing the results toward the domain of interest;

• Normal aging: the cases with the scores of cognitive performance within 1.5 standard deviation (SD) of age and education matched normative values derived from our cohort study, of which presented with HK MoCA score greater than 26 and CDR score equal to 0;

• NCD patients are de?ned as: evidence of modest decline in one or more cognitive domains, which is set as = 1.5 SD below the age- and education-adjusted normative scores; no interference with independence in everyday activities; and no comorbid major psychiatric disorders.

Exclusion Criteria:

• History of bipolar disorders or psychosis;

• History of major neurological de?cits including stroke, transient ischemic attack or traumatic brain injury;

• Comorbidities with depressive symptoms.

Related Conditions & MeSH terms

• Age-related Cognitive Decline
• Cognitive Deterioration
• Cognitive Dysfunction
• Dementia, Mild

Intervention

Diagnostic Test:
• Ageing
Using comprehensive cognitive tests to quality the domain-specific cognitive changes during ageing.

Locations

Country	Name	City	State
Hong Kong	Tai Po Hospital	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
Chinese University of Hong Kong

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Global cognition will be measured by the Montreal Cognitive Assessment Hong Kong version (HK MoCA)	The Montreal Cognitive Assessment Hong Kong version (HK MoCA) is a validated and widely used screening assessment for detecting cognitive impairment, which measures an array of cognitive functions such as visuospatial, memory, language and attention.HK MoCA score less than 26 indicates cognitive impairments.	2022-2024
Primary	Complex attention will be measured by Attention Network Test (ANT)	Attention Network Test (ANT). The ANT paradigm (Download from: https://www.sacklerinstitute.org/cornell/assays_and_tools/ant/jin.fan/), as a computerized test, was used and performed by E-Prime 3.0 (Psychology Software Tools, PA, USA). Within ANT paradigm, there are four types of cue: no cue, center cue, double cue, and spatial cue; and three types of ?anker: neutral, congruent, and incongruent. In a given trial, a central cross-?xation point presents for 400 to 1,600 ms (randomized), subsequently is replaced for 100 ms by one of four warning cues. The target, a central arrow could appear above or below the cross-?xation and is surrounded by two ?ankers on each side.	2022-2024
Secondary	Learning and memory will be measured by Word list learning test (WLLT)	Word list learning test (WLLT) consisting of fifteen semantically non-associated words that is presented consecutively over three free trials of immediate recall (i.e., learning ability), a 20-min delayed recall (to prevent recency effects) and followed by yes/no recognition (i.e., recognition memory). Based on the proxies we developed in our previous work, components of learning and memory function will be evaluated and compared across groups, including working memory capacity (WMC), forgetting rate, delayed recall, initial learning, best learning, learning over trials (LOT) and learning ratio.	2022-2024

External Links

•   Hong Kong SuperAgers