The Dortmund Vital Study: Impact of Biological & Lifestyle Factors on

Status Active, not recruiting

Clinical Trial Summary

The goal of the Dortmund Vital Study is to validate previous hypotheses and to generate and validate new hypotheses about the relationship of ageing, working conditions, genetic makeup, stress, metabolic functions, cardiovascular system, immune system, and mental performance over the lifespan with a focus on healthy working adults. The Dortmund Vital Study is a multidisciplinary longitudinal study involving the Departments of Ergonomics, Immunology, Psychology and Neurosciences, and Toxicology of the Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo) in Dortmund, Germany, as well as several national and international cooperation partners.

Clinical Trial Description

The Dortmund Vital Study is designed as a combined cross-sectional and longitudinal study. About 600 subjects aged between 20 and 70 years will participate. A wide range of demographic, psychological, behavioral, sensory, cardiovascular, biochemical, immunological and biochemical data, a comprehensive EEG-based cognitive test battery as well as structural and functional magnetic resonance imaging (MRI) have been included in the study. Specifically, parameters obtained by MRI and EEG-related measures can be evaluated as a function of polygenic scores, metabolic products, concentration of immune cells, immune age and infections, such as Toxoplasmosis or COVID-19 that are largely unexplored. The same is true for environmental and lifestyle factors that impact on brain activity and behavior. The initial testing has been conducted between 2016 and 2021 and will be repeated every five years (three follow-up measures until 2035). The study will shed light on sources of large inter-individual differences in cognitive functioning with increasing age and reveal biological and lifestyle markers contributing to work ability, longevity and healthy aging on the one hand, and on risk factors for cognitive decline, mild cognitive impairment or even dementia on the other. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05155397
Study type	Observational
Source	Technical University of Dortmund
Contact
Status	Active, not recruiting
Phase
Start date	April 2016
Completion date	December 2037

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04121728` - Modulation of Attention in Event Related Potential (ERPs) as a Marker of Early Cognitive Decline by Ginkgo Biloba	N/A
Enrolling by invitation	`NCT04641663` - Multi-target Dietary Supplement Tolerability in an Aging Population (MTDSST)	N/A
Completed	`NCT03228446` - The Effects of Attentional Filter Training on Working Memory	N/A
Completed	`NCT04910399` - Development of an Innovative Health Ingredient From Marine By-products for the Healthy Aging	N/A
Recruiting	`NCT03275363` - The University of Hong Kong Neurocognitive Disorder Cohort	N/A
Completed	`NCT02185222` - Effect of Vitamin D on Cognitive Decline of Patients With Memory Complaint	Phase 3
Completed	`NCT03162913` - The Effects of Strawberry Supplementation on Memory and Gait Among Over-weight Older Adults	N/A
Completed	`NCT02416401` - Attention Training for Learning Enhancement and Resilience Trial	N/A
Completed	`NCT02922920` - Effects of Tart Cherry Juice on the Body	N/A
Completed	`NCT01120860` - Magnetic Resonance Imaging (MRI) and Decline of Aging Aviator Performance	N/A
Recruiting	`NCT03702335` - Impact of Comprehensive Dietary Counseling on Dietary Quality, Mental Health, and Quality of Life in Older Adults	N/A
Completed	`NCT05828043` - Brain Aging: Muscle-to-brain Axis Modulates Physio-cognitive Decline	N/A
Active, not recruiting	`NCT05348694` - OsteoPreP: Food Supplements for Postmenopausal Bone Health	Phase 4
Recruiting	`NCT05194787` - TAS Test: Online Motor-cognitive Tests for Early Detection of Alzheimer's Disease
Recruiting	`NCT04184375` - Cognitive Stimulation for Elderly Bipolar Patients	N/A
Recruiting	`NCT04171323` - The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia	N/A
Not yet recruiting	`NCT06248723` - ItaliaN Study With Tailored Multidomain Interventions to Prevent Functional and Cognitive Decline in Community-dwelling Older Adults	N/A
Terminated	`NCT04732312` - Impact of Formal Home Help on Quality of Life for Caregivers of Elderly Patients With Neurocognitive Impairment
Recruiting	`NCT06377254` - Multi-organ Responses to CHronic Physical Activity and INactivity	N/A
Not yet recruiting	`NCT04566757` - Safety and Efficacy of Human Umbilical Cord Blood Plasma Infusion for Age-Related Cognitive Decline	Phase 1

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability — DVS

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms