Age-related Cognitive Decline Clinical Trial
Official title:
Train the Brain With Music: Brain Plasticity and Cognitive Benefits Induced by Musical Practice in Elderly People in Germany and Switzerland
This longitudinal study aims to countervail age-related cognitive and cerebral decline in healthy retired people through intensive piano / keyboard music practice in Switzerland and Germany.
Recent data suggest that music making might prevent cognitive decline in the elderly. However, experimental evidence remains sparse and no information on the neurophysiological basis has been provided, although cognitive decline is a major impediment to healthy aging. This study combines for the first time protocolled music practice in elderly with cutting-edge neuroimaging. The investigators propose a multi-site Hannover-Geneva longitudinal randomized intervention study in altogether 100 retired healthy elderly (64-76) years, 70 Geneva, 100 Hannover), offering either piano instruction or instruction on musical culture for one year. Participants will be tested at 3 time points on cognitive, perceptual and motor abilities as well as via wide-ranging functional and structural neuroimaging data (Magnetic Resonance Imaging, MRI). The research team expects positive transfer effects from intensive piano training not only on subjective well-being, but also on executive functions, working memory, hearing in noise and relationships of these behavioral features with morphological and functional brain plasticity. This study may therefore for the first time be demonstrate, that music making can provoke important societal impacts by diminishing cognitive and perceptual-motor decline underpinned by functional and structural brain plasticity. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04121728 -
Modulation of Attention in Event Related Potential (ERPs) as a Marker of Early Cognitive Decline by Ginkgo Biloba
|
N/A | |
| Enrolling by invitation |
NCT04641663 -
Multi-target Dietary Supplement Tolerability in an Aging Population (MTDSST)
|
N/A | |
| Completed |
NCT03228446 -
The Effects of Attentional Filter Training on Working Memory
|
N/A | |
| Completed |
NCT04910399 -
Development of an Innovative Health Ingredient From Marine By-products for the Healthy Aging
|
N/A | |
| Recruiting |
NCT03275363 -
The University of Hong Kong Neurocognitive Disorder Cohort
|
N/A | |
| Completed |
NCT02185222 -
Effect of Vitamin D on Cognitive Decline of Patients With Memory Complaint
|
Phase 3 | |
| Completed |
NCT03162913 -
The Effects of Strawberry Supplementation on Memory and Gait Among Over-weight Older Adults
|
N/A | |
| Completed |
NCT02416401 -
Attention Training for Learning Enhancement and Resilience Trial
|
N/A | |
| Completed |
NCT02922920 -
Effects of Tart Cherry Juice on the Body
|
N/A | |
| Completed |
NCT01120860 -
Magnetic Resonance Imaging (MRI) and Decline of Aging Aviator Performance
|
N/A | |
| Recruiting |
NCT03702335 -
Impact of Comprehensive Dietary Counseling on Dietary Quality, Mental Health, and Quality of Life in Older Adults
|
N/A | |
| Completed |
NCT05828043 -
Brain Aging: Muscle-to-brain Axis Modulates Physio-cognitive Decline
|
N/A | |
| Active, not recruiting |
NCT05348694 -
OsteoPreP: Food Supplements for Postmenopausal Bone Health
|
Phase 4 | |
| Recruiting |
NCT05194787 -
TAS Test: Online Motor-cognitive Tests for Early Detection of Alzheimer's Disease
|
||
| Recruiting |
NCT04184375 -
Cognitive Stimulation for Elderly Bipolar Patients
|
N/A | |
| Recruiting |
NCT04171323 -
The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
|
N/A | |
| Not yet recruiting |
NCT06248723 -
ItaliaN Study With Tailored Multidomain Interventions to Prevent Functional and Cognitive Decline in Community-dwelling Older Adults
|
N/A | |
| Terminated |
NCT04732312 -
Impact of Formal Home Help on Quality of Life for Caregivers of Elderly Patients With Neurocognitive Impairment
|
||
| Recruiting |
NCT06377254 -
Multi-organ Responses to CHronic Physical Activity and INactivity
|
N/A | |
| Not yet recruiting |
NCT04566757 -
Safety and Efficacy of Human Umbilical Cord Blood Plasma Infusion for Age-Related Cognitive Decline
|
Phase 1 |