Different Order of Concurrent Training on Improving Visceral Adipose Tissue and Insulin Resistance.

Aerobic Exercise Clinical Trial

Official title:

The Effect of Different Order of Concurrent Training Consisting Aerobic and Resistance Exercise on Improving Visceral Adipose Tissue and Insulin Resistance for Community Residents With Obesity.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05580263
• Other study ID #: 110-551
• Status: Completed
• Phase: N/A
• Start date: October 31, 2022
• Est. completion date: June 30, 2023

Study information

• Verified date: February 2024
• Source: National Tainan Junior College of Nursing
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Purposes: The purpose of one-year project is to compare the effect of different intrasession exercise order of AE and RE during concurrent training on reducing VAT and improving insulin resistance for inactive middle-age community residents with obesity.

Methods: Purposive sampling will be used to enroll community residents aged 40-64 years with inactive habit and body fat percentage ≧ 25% for male and ≧ 30% for female in southern Taiwan. Eligible participants will be stratified by sex and age (40-55years and 56-64 years) then block randomly divided into training group of AE preceding RE, RE preceding AE or a control group. The exercise training program will under supervision lasting 16 weeks with 3 times per week. The concurrent training prescription consist of AE 30 minutes and RE 15 minutes per session. A 5-minute interval between two exercise modalities. All participants will be evaluated outcomes for two time points including baseline (T0) and after 16-week intervention (T1). The primary outcomes are VAT and insulin resistance. A two-way ANOVA with repeated measures will be performed to compare changes of outcome variables over the intervention period.

Relevance to clinical practice: The results of this project can assist health professionals to know how to properly prescribe concurrent training of AE and RE to achieve the greatest effects on VATreduction and insulin resistance improvement for middle-age residents with obesity.

Description:

Background: Visceral adipose tissue (VAT) accumulation is highly linking with cardiovascular diseases and insulin resistance. A combination of aerobic exercise (AE) and resistance exercise (RE) was an effective strategy to improve VAT and insulin resistance; however, no current evidence displayed whether the different orders of concurrent training (AE preceding RE or RE preceding AE) influence the effects on VAT reduction and insulin resistance improvement.

Purposes: The purpose of one-year project is to compare the effect of different intrasession exercise order of AE and RE during concurrent training on reducing VAT and improving insulin resistance for inactive middle-age community residents with obesity.

Methods: Purposive sampling will be used to enroll community residents aged 40-64 years with inactive habit and body fat percentage ≧ 25% for male and ≧ 30% for female in Tainan. Eligible participants will be stratified by sex and age (40-55years and 56-64 years) then block randomly divided into training group of AE preceding RE, RE preceding AE or a control group. The exercise training program will under supervision lasting 16 weeks with 3 times per week. The concurrent training prescription consist of AE 30 minutes and RE 15 minutes per session. A 5-minute interval between two exercise modalities. The control group will follow their primary lifestyle without exercise intervention. All participants will be evaluated outcomes for two time points including baseline (T0) and after 16-week intervention (T1). The primary outcomes are VAT and insulin resistance. VAT is measured by body composition analyzer and insulin resistance is calculate from fasting glucose and insulin level in blood samples. A two-way ANOVA with repeated measures will be performed to compare changes of outcome variables over the intervention period.

Relevance to clinical practice: The results of this project can assist health professionals to know how to properly prescribe concurrent training of AE and RE to achieve the greatest effects on VATreduction and insulin resistance improvement for middle-age residents with obesity.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 92
• Est. completion date: June 30, 2023
• Est. primary completion date: June 30, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 40 Years to 64 Years

Eligibility

Inclusion Criteria:

• 40 to 64 years old.

• body fat percentage ? 25% for male and ? 30% for female.

• with inactive habit (= 3 days of physical activity per week and = 30 min per session).

• can communicate in Mandarin or Taiwanese.

Exclusion Criteria:

• with recent unstable conditions in which had potential risk on exercise including stroke, cardiovascular and respiratory diseases, handicap, pregnancy.

• with any contraindications to body composition analyzer measurement including body embed pacemakers and artificial metal joints, amputated hands or feet.

• cannot corporate with either examination or intervention.

• use psychotropic or appetite-regulating medicine.

• under oral hopoglycemic agent or insulin treatment.

Related Conditions & MeSH terms

• Aerobic Exercise
• Fat Burn
• Insulin Resistance
• Resistance Exercise

Intervention

Behavioral:
• aerobic exercise
The main AE program will be designed and controlled for at least moderate intensity of heart rate reserve (HRR) lasting 30 minutes. The goal of intensity will be set at least 40% of HRR during the first two weeks, and then progressively increase the targeted intensity at the end of 16 weeks with 60% HRR. The motions will design by involving core muscle training (e.g., march, step touch, lunge, V-step, box step, twist, knee up, scoop, and scissors).
• resistance exercise
In the process, the participants will be instructed by resisting the weight smoothly, and peaking at hold. RE prescription consist of 2-4 sets with 10-15 repetitions per set with a rest interval of 1-2 minutes between sets to improve muscular fitness. The first two weeks will start with two sets of 10-15 repetitions and then gradually progress on four sets of 15 repetitions at the end of 16 weeks. The total duration of RE will lasting around 15 minutes.

Locations

Country	Name	City	State
Taiwan	Natioal Tainan Junior College of Nursing	Tainan

Sponsors (1)

Lead Sponsor	Collaborator
National Tainan Junior College of Nursing

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	visceral adipose tissue	Participants will measure visceral adipose tissue measure at baseline by body composition analyzer.	at baseline
Primary	visceral adipose tissue	Participants will measure visceral adipose tissue measure after 16-week intervention by body composition analyzer.	16-week after intervention
Primary	Insulin	Participants will collect insulin at baseline by blood samples	at baseline
Primary	Insulin	Participants will collect insulin after 16-week intervention by blood samples	16-week after intervention
Primary	Fasting glucose	Participants will collect fasting glucose at baseline by blood samples	at baseline
Primary	Fasting glucose	Participants will collect fasting glucose after 16-week intervention by blood samples	16-week after intervention
Secondary	waist circumference	Participants will measure waist circumference at baseline by tape measurement	at baseline
Secondary	waist circumference	Participants will measure waist circumference after 16-week intervention by tape measurement	16-week after intervention
Secondary	hip circumference	Participants will measure hip circumference at baseline by tape measurement	at baseline
Secondary	hip circumference	Participants will measure hip circumference after 16-week intervention by tape measurement	16-week after intervention
Secondary	weight	Participants will measure weight at baseline by body composition analyzer	at baseline
Secondary	weight	Participants will measure weight after 16-week intervention by body composition analyzer	16-week after intervention
Secondary	body fat percentage	Participants will measure body fat percentage at baseline by body composition analyzer	at baseline
Secondary	body fat percentage	Participants will measure body fat percentage after 16-week intervention by body composition analyzer	16-week after intervention