Aerobic Exercise Clinical Trial
Official title:
Diurnal Variation of the Effect of Aerobic Exercise on Glycemic Metabolism and Fat Oxidation in Humans: Role of Sex
The main objective of this project is to study the diurnal variation of the effect of exercise on glycemic metabolism and fat oxidation in humans.
Strong scientific evidence supports the beneficial effects of exercise on cardiovascular health, the regulation of glucose metabolism, and fat oxidation. Physical performance capacity is known to fluctuate throughout the day, however, it is unknown whether there is an optimal time of day to maximize the effects of exercise on health, and specifically on blood glucose metabolism and fat oxidation. Finding the ideal time to perform physical exercise is of clinical and public health interest. Likewise, optimizing the timing of physical exercise to coincide with the greater physiological response of each individual would mean increasing the potential of exercise as a therapeutic tool. Specific aims of this project are a) to describe possible differences dependent on sex in the diurnal variation of the effect of exercise on glycemic metabolism and fat oxidation, and b) to characterize the molecular mechanisms implicated. 18 men and 17 women with normal weight will be randomized into two conditions (morning and evening) with at least 3 days of separation in between. Each evaluation will conform the following tests: 1. Basal metabolic rate assessment through indirect calorimetry during 30 minutes. 2. Fuel oxidation and energy expenditure assesment during a 60 minutes bout of aerobic steady-state exercise (cycling), through indirect calorimetry. 3. Fuel oxidation and energy expenditure assesment after exercise during 30 minutes, through indirect calorimetry. 4. Blood samples assesment before, inmediately after, and 90 minutes after exercise. 5. Quadriceps biopsies before, and inmediately after exercise. *This will be done only in a sub-cohort. 6. Visual analog scales to assess appetite before, inmediately after, and 90 minutes after exercise. 7. Continous glucose monitoring from the previous 24 hrs to first session day, until 48 hrs after the last exercise session. Previous to this, participants' body composition and fitness level will be assesed via densitometry and a maximal exercise test, respectively. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT06309654 -
Home-Based Circuit Training in Overweight/Obese Older Adult Patients With Knee Osteoarthritis and Type 2 Diabetes
|
N/A | |
| Completed |
NCT05580263 -
Different Order of Concurrent Training on Improving Visceral Adipose Tissue and Insulin Resistance.
|
N/A | |
| Not yet recruiting |
NCT04121637 -
To Investigate the Effect of Aerobic Exercise on Neurophysiological Values and Functionality in Individuals With Multiple Sclerosis.
|
N/A | |
| Completed |
NCT02541136 -
Neural Changes of Exercise: a Functional MRI Study
|
N/A | |
| Recruiting |
NCT06084455 -
TMS-evoked Potentials During Aerobic Exercise
|
N/A | |
| Completed |
NCT04288830 -
Evaluation of a Tai Chi Resilience Training Program on Objective and Subjective Measures of Post Traumatic Stress Disorder Severity
|
N/A | |
| Active, not recruiting |
NCT06105697 -
Effects of Aerobic Blood Flow Restriction
|
N/A | |
| Completed |
NCT04068285 -
Neuromuscular Adaptations to Exercise In Patients With Type 2 Diabetes Mellitus
|
N/A | |
| Recruiting |
NCT06152614 -
MIND Foods and Aerobic Training in Black Adults With HTN
|
N/A | |
| Completed |
NCT04856280 -
Kinesiological Taping and Aerobic Exercise in Women With Primary Dysmenorrhea:
|
N/A | |
| Recruiting |
NCT02648945 -
Effects of Low and High Intensity Exercise in Improving Working Memory Among Students With Anxiety Symptoms
|
N/A | |
| Completed |
NCT02327975 -
Prescription of Physical Exercise Through Mobile Application in Elderly
|
N/A | |
| Completed |
NCT03759509 -
Effects of Aerobic Exercise Training on Nurses' Sleep Quality, Fatigue, Attention and Cortisol Profile
|
N/A | |
| Completed |
NCT05987436 -
Effect of Aerobic Exercise in Patients With Essential Hypertension
|
||
| Completed |
NCT05839743 -
Investigation of the Effects of Aerobic Exercise, Balance Exercise and Combined Exercise Practices on Frailty, Balance, Fall Risk, Reaction Time, Cognitive Functions and Quality of Life in Dementia Patients
|
N/A | |
| Not yet recruiting |
NCT06413940 -
Exploring the Clinical Efficacy of Remote Management Applications Through Comprehensive Physical Therapy for Patients With Moderate to Severe Sleep Apnea
|
N/A | |
| Completed |
NCT05235958 -
VascuFit: Exercise and Vascular Aging
|
N/A | |
| Enrolling by invitation |
NCT05352334 -
Comparison of High Intensity Interval Training Verses Aerobic Exercises on Emotional Intelligence of University Students
|
N/A | |
| Terminated |
NCT01644812 -
Lifestyle Interventions for Generalized Anxiety Disorder
|
N/A | |
| Active, not recruiting |
NCT01475396 -
The Effect of Physical Activity on the Brain
|
Phase 3 |