View clinical trials related to Adverse Effect.
Filter by:The purpose of the study is to determine if an intravenous bolus of phenylephrine is more effective compared to an intravenous bolus of norepinephrine associated with crystalloid loading for maintaining blood pressure during a spinal anesthetic for a cesarean delivery. Prevention of low blood pressure has been shown to decrease nausea and vomiting during and after cesarean delivery under spinal anesthesia. For elective cesarean delivery, all participants will receive spinal anesthesia with a local anesthetic and sufentanil. This study plans to enroll 120 pregnant women. Patients will be randomly assigned according to a computer generated system to be in one of two groups.
The purpose of this study is to investigate the efficacy of dezocine pretreatment on dexamethasone 21-phosphate induced perineal irritation (include pian and pruritus).
Dental staining is the most common local side effect of chlorhexidine (CHX) mouthwashes. A prospective, cross-over, randomized clinical trial will be carried out in triple blind to compare the effect on dental staining of two 0.12% CHX mouthwashes: with or without ADS. Twenty-two healthy subjects will be enrolled. Briefly, the study includes two sequential stages: in the first phase, we record the "immediate" objective and subjective evaluation of dental discoloration by spectroscopic and questionnaire-based analyses, at baselines and after each 21 days long-cycle of mouthwash. A wash-out period between the cycles of 21 days is performed. In the second phase, a long-term (after 6 months) subjective evaluation of dental discoloration was obtained by means of clinical photograph visual analysis and new questionnaires.