View clinical trials related to Adverse Effect.
Filter by:The purpose of this study is to investigate the efficacy of dezocine pretreatment on dexamethasone 21-phosphate induced perineal irritation (include pian and pruritus).
Dental staining is the most common local side effect of chlorhexidine (CHX) mouthwashes. A prospective, cross-over, randomized clinical trial will be carried out in triple blind to compare the effect on dental staining of two 0.12% CHX mouthwashes: with or without ADS. Twenty-two healthy subjects will be enrolled. Briefly, the study includes two sequential stages: in the first phase, we record the "immediate" objective and subjective evaluation of dental discoloration by spectroscopic and questionnaire-based analyses, at baselines and after each 21 days long-cycle of mouthwash. A wash-out period between the cycles of 21 days is performed. In the second phase, a long-term (after 6 months) subjective evaluation of dental discoloration was obtained by means of clinical photograph visual analysis and new questionnaires.