Bupropion Stereoselective Disposition and CYP2D6-mediated Drug Interactions in Healthy Volunteers

Adverse Effect of Drug Therapy Metabolism Medications (Diagnosis) Clinical Trial

Official title: Bupropion Stereoselective Disposition and CYP2D6-mediated Drug Interactions in Healthy Volunteers

Status Completed

Clinical Trial Summary

Primary objectives:

1. To comprehensively characterize steady state stereoselective pharmacokinetics of bupropion and its primary and secondary metabolites in healthy volunteers

2. To prospectively determine the time course (onset), extent and offset of CYP2D6 inhibition in relation to the pharmacokinetic profiles of bupropion and metabolites.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Adverse Effect of Drug Therapy Metabolism Medications (Diagnosis)
• Drug-Related Side Effects and Adverse Reactions

• NCT number: NCT03420469
• Study type: Interventional
• Source: Indiana University
• Status: Completed
• Phase: Early Phase 1
• Start date: June 5, 2018
• Completion date: May 1, 2019