A Study of KL590586 in Patients With Advanced Solid Tumors

Status Enrolling by invitation

Clinical Trial Summary

An Open, Multi-Center Phase I/II Clinical Study To Evaluate The Safety, Tolerability, Pharmacokinetic Characteristics And Effectiveness Of KL590586 Capsules In Patients With Advanced Solid Tumors Carrying RET Fusion Or Mutant Genes

Clinical Trial Description

This is an open, multicentre phase I/II study. To evaluate the safety, tolerability, pharmacokinetic/pharmacodynamic properties and efficacy of KL590586 in patients with advanced NSCLC, MTC and other solid tumours carrying a RET fusion or mutation gene. Phase I of this study includes a dose-escalation phase and a dose-expansion phase (as needed), which will focus on exploring MTD and/or RP2D of KL590586 in patients with advanced solid tumours; Phase II will assess the efficacy and safety of KL590586 in different cohorts (NSCLC, MTC and other tumour types carrying RET fusions or mutations) of solid tumour patients at the RP2D dose. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05265091
Study type	Interventional
Source	Sichuan Kelun Pharmaceutical Research Institute Co., Ltd.
Contact
Status	Enrolling by invitation
Phase	Phase 1/Phase 2
Start date	June 1, 2021
Completion date	May 30, 2025

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