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Study of RP3 Monotherapy and RP3 in Combination With Nivolumab in Patients With Solid Tumours

Advanced Solid Tumor Clinical Trial

Official title:
An Open-Label, Multicenter, Phase 1 Study of RP3 as a Single Agent and in Combination With PD-1 Blockade in Patients With Solid Tumors

Clinical Trial Summary

This is a Phase 1, multicenter, open label, single agent dose escalation and combination treatment study of RP3 in adult participants with advanced solid tumors, to evaluate the safety and tolerability of RP3 both as a single agent and in combination with anti-PD1 therapy and to determine the recommended Phase 2 dose (RP2D) of RP3.

Clinical Trial Description

RP3 is a genetically modified herpes simplex type 1 virus (HSV-1) that expresses exogenous genes (anti-CTLA-4 antibody, CD40 ligand and h4-1BBL) designed to directly destroy tumors and generate an anti-tumor immune response ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04735978
Study type Interventional
Source Replimune Inc.
Contact
Status Active, not recruiting
Phase Phase 1
Start date December 29, 2020
Completion date April 2024
View Details
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