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Safety and Tolerability Study for T-1101 (Tosylate) Capsules to Treat Advanced Refractory Solid Tumors

Advanced Refractory Solid Tumors Clinical Trial

Official title:
A Phase I Study of Safety, Tolerability and Pharmacokinetics of T-1101 (Tosylate) Capsules in Subjects With Advanced Refractory Solid Tumors

Clinical Trial Summary

T-1101 (Tosylate) is a new small molecule chemical entity being developed as a potential anti-cancer therapeutic by Taivex Therapeutics Corp. T-1101 (Tosylate) is a potent anti-cancer agent in numerous human cancer cell lines. In addition, oral administration of T-1101 (Tosylate) showed tumor growth inhibition in different mouse xenograft models of human cancers. In this study, safety, tolerability and pharmacokinetic (PK) of T-1101 (Tosylate) capsules will be evaluated and also the recommended dose and regimen(s) to initiate Phase 2 will be determined.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04685473
Study type Interventional
Source Taivex Therapeutics Corporation
Contact
Status Active, not recruiting
Phase Phase 1
Start date January 7, 2021
Completion date July 31, 2024
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See also
  Status Clinical Trial Phase
Suspended NCT01762410 - Clinical Study of Oral PI3K/mTOR Inhibitor in Patients With Advanced Refractory Solid Tumors Phase 1
Completed NCT03349073 - An Extension Study for T-1101 (Tosylate) to Treat Advanced Refractory Solid Tumors Phase 1
Terminated NCT03195764 - Safety and Tolerability Study for T-1101 (Tosylate) to Treat Advanced Refractory Solid Tumors Phase 1
Recruiting NCT04892498 - Hypofractionated Radiotherapy Combined With PD-1 Inhibitor Sequential GM-CSF and IL-2 for the Treatment of Advanced Refractory Solid Tumors (PRaG2.0) Phase 2
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Recruiting NCT03863145 - Study to Evaluate Maximum Tolerated Dose of Oral CB-03-10 With Dose Expansion Phase, in Advanced Solid Tumors Early Phase 1
Completed NCT04324372 - Clinical Study of HEC68498 in Patients With Advanced Refractory Solid Tumors Phase 1
Recruiting NCT02300467 - NOV120401 (CKD-516 Tablet) for Advanced Solid Tumors Phase 1
Suspended NCT01779336 - Clinical Study of Oral IGF-1R Inhibitor in Subjects With Advanced Refractory Solid Tumors Phase 1
Completed NCT04200404 - A Study of CS1001 in Combination With Regorafenib in Patients With Advanced or Refractory Solid Tumors Phase 1/Phase 2