Advanced Parkinson's Disease Clinical Trial
Official title:
Phase 1 Study To Assess the Safety and Tolerability of Human Embryonic Stem Cell-Derived Midbrain Dopamine Neuron Cell Therapy (MSK-DA01) For Advanced Parkinson's Disease
This clinical trial is designed to test whether surgically injecting nerve cells that make dopamine into the brain of Parkinson's disease patients is safe, and to monitor for potential side effects.
Subjects will undergo surgical transplantation of the dopamine-producing cells under general anesthesia into a part of the brain called the putamen. Subjects then take medicines to partially suppress their immune system (aimed to prevent the body from rejecting the cells) for 1 year. Safety, tolerability, evidence of cell survival (using MRI and PET scans of the brain), and effect on Parkinson's disease symptoms are assessed for 2 years post-transplant. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT02154724 -
Clinical Study for Adaptive Deep Brain Stimulation (aDBS)Controlled by Intracerebral Activity in Parkinson's Disease
|
N/A | |
| Completed |
NCT02549092 -
A Study to Examine the Effect of Levodopa-Carbidopa Intestinal Gel (LCIG) Therapy Relative to That of Optimized Medical Treatment (OMT) on Non-motor Symptoms (NMS) Associated With Advanced Parkinson's Disease (PD)
|
Phase 3 | |
| Completed |
NCT01960842 -
A Study to Assess the Efficacy, Safety and Tolerability of ABT-SLV187 Monotherapy in Subjects With Advanced Parkinson's Disease (PD) and Persistent Motor Complications, Despite Optimized Treatment With Available Anti-Parkinsonian Medications
|
Phase 3 | |
| Completed |
NCT01723904 -
A Phase 3b, Open-Label, Safety and Efficacy Study of Rotigotine as Add-On Therapy With Low Doses of Pramipexole or Ropinirole in Patients With Advanced Parkinson's Disease
|
Phase 3 | |
| Completed |
NCT01479127 -
Study of Safety, Tolerability, Pharmacokinetics, and Efficacy of ABT-SLV187 in Subjects With Advanced Parkinson's Disease
|
Phase 2 | |
| Completed |
NCT03007888 -
A Study to Assess the PK and Pharmacodynamics of IPX203 in Subjects With Advanced Parkinson's Disease
|
Phase 2 | |
| Completed |
NCT00660673 -
Open Label Continuation Treatment Study With Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson's Disease
|
Phase 3 | |
| Completed |
NCT01736176 -
A Study to Assess the Safety and Efficacy of Levodopa-carbidopa Intestinal Gel (LCIG) for the Treatment of Non-motor Symptoms in Patients With Advanced Parkinson's Disease
|
Phase 3 | |
| Completed |
NCT02082249 -
An Extension Study to Assess the Safety, Tolerability and Efficacy of ABT-SLV187 in Subjects With Advanced Parkinson's Disease and Persistent Motor-Complications Despite Optimized Treatment With Available Anti-Parkinsonian Medications
|
Phase 3 | |
| Completed |
NCT02611713 -
Observational Study Evaluating Long-Term Effectiveness of Duodopa/Duopa in Patients With Advanced Parkinson's Disease
|
||
| Terminated |
NCT01536015 -
Effect of Rotigotine on Motor Symptoms in Patients With Advanced Parkinson's Disease (PD) With Motor Fluctuations and Symptoms of Gastrointestinal Dysfunction
|
Phase 3 | |
| Completed |
NCT00357994 -
Study of Efficacy, Safety and Tolerability of Levodopa-Carbidopa Intestinal Gel in Levodopa-Responsive Parkinson's Subjects
|
Phase 3 | |
| Completed |
NCT00335153 -
Levodopa-Carbidopa Intestinal Gel Open-Label Study in Advanced Parkinson's Disease
|
Phase 3 | |
| Active, not recruiting |
NCT06396494 -
An Automated Navigation System for Deep Brain Electrode Implantation
|
||
| Recruiting |
NCT06195124 -
A Study on the Safety and Tolerability of RGL-193 in Patients With Advanced Parkinson's Disease
|
Early Phase 1 | |
| Completed |
NCT00660387 -
Study of Efficacy, Safety and Tolerability of Levodopa-Carbidopa Intestinal Gel in Levodopa-Responsive Parkinson's Subjects
|
Phase 3 |