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Clinical Trial Summary

The primary objective is to determine the safety and tolerability of SH3765 in subjects with advanced malignant tumor by determining the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D). The second objective is to evaluate the PK profile and preliminary efficacy of SH3765 in subjects with advanced malignant tumor.


Clinical Trial Description

This is a Phase I, open-label, multicenter, multidose, two-part study to assess the safety, tolerability, PK and preliminary efficacy of SH3765, a protein arginine methyltransferase 5 (PRMT5) inhibitor, in subjects with advanced malignant tumor including but not limited to solid tumor and non-Hodgkin lymphoma. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05015309
Study type Interventional
Source Nanjing Sanhome Pharmaceutical, Co., Ltd.
Contact Ruihua Xu, PhD
Phone 86-20-87343468
Email xurh@sysucc.org.cn
Status Not yet recruiting
Phase Phase 1
Start date September 2021
Completion date September 2024

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