Treatment of Advanced Malignant Solid Tumors With Claudin18.2CAR-T

Status Recruiting

Clinical Trial Summary

The efficacy of advanced pancreatic cancer and gastric cancer needs to be further improved. Claudin is a kind of integrin membrane protein in the tight junction between epithelium and endothelium, which is highly expressed in gastric cancer and pancreatic cancer. Preclinical studies suggest that Claudin18.2CAR-T can effectively improve the remission rate of patients with advanced solid tumors.

Clinical Trial Description

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05620732
Study type	Interventional
Source	Shenzhen University General Hospital
Contact	Li Yu, Dr
Phone	+8675521839178
Email	liyu@vip.163.com
Status	Recruiting
Phase	N/A
Start date	October 1, 2022
Completion date	October 31, 2028

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05545293` - Prospective Study on Double-Stapling End-to-End Gastroduodenostomy Billroth-I Anastomosis in Laparoscopy-Assisted Surgery for Locally Advanced Distal Gastric Cancers
Completed	`NCT04808791` - iTTo for Treatment Naive Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma	Phase 2
Recruiting	`NCT05221775` - Safety of XELOX Combined With GLS-010 and Lenvatinib in Advanced AFP-positive Gastric Cancer Patients	Phase 1
Completed	`NCT05334849` - Prospectively Predict the Immunotherapy Response of Gastric Cancer Based on Circulating Exosomal LncRNA-GC1 Biopsy
Not yet recruiting	`NCT05313906` - RC48 Plus AK105 and Cisplatin in Advanced Gastric Cancer	Phase 2
Completed	`NCT00192088` - A Study of Pemetrexed Plus Oxaliplatin as First Line Therapy in Advanced Gastric Carcinoma	Phase 2
Terminated	`NCT04718402` - A Study of Mitoxantrone Hydrochloride Liposome Injection in the Treatment of Advanced Gastric Carcinoma	Phase 1
Active, not recruiting	`NCT01534546` - Phase III Study to Compare Perioperative Chemotherapy of Oxaliplatin Combined With S-1(SOX) Versus SOX or Oxaliplatin With Capecitabine (XELOX) as Post-operative Chemotherapy in Locally Advanced Gastric Adenocarcinoma With D2 Dissection	Phase 3
Recruiting	`NCT04739202` - Personalized Targeted IMMUNOtherapy-based Regimens in Recurrent GASTric Adenocarcinoma (IMMUNOGAST)	Phase 2
Not yet recruiting	`NCT05270824` - Study Evaluating Neoadjuvant Immunotherapy Increasing CD8+ Cell Infiltration in Advance Gastric Adenocarcinoma	Phase 3
Completed	`NCT05997524` - Clinical Efficacy of Trastuzumab in Combination With Capecitabine and Oxaliplatin for the Treatment of HER2-positive Advanced Gastric Cancer.	Phase 2
Recruiting	`NCT06264921` - A Study With NKT3447 for Adults With Advanced/Metastatic Solid Tumors	Phase 1
Recruiting	`NCT05805956` - IMM2902 in Patients With Advanced Solid Tumors Expressing HER2	Phase 1/Phase 2
Not yet recruiting	`NCT02163291` - Study on Neoadjuvant Chemotherapy for Advanced Gastric Cancer	Phase 2
Recruiting	`NCT04704661` - Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Patients With Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial	Phase 1
Recruiting	`NCT06028737` - Total Neoadjuvant Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Cancer	Phase 2/Phase 3
Active, not recruiting	`NCT04491942` - Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer	Phase 1
Recruiting	`NCT05969860` - At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer	Phase 2
Active, not recruiting	`NCT04535401` - Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines	Phase 1
Recruiting	`NCT05226169` - Efficacy and Safety oF FErric CarboxymalTose in Patients With Advanced Gastric Cancer(EFFECT-AGC)	Phase 3