Advanced Gastric Cancer Clinical Trial
Official title:
Randomized Controlled Trials on Adjuvant Intraperitoneal Chemotherapy for Resectable Local Advanced Gastric Cancer
Gastric cancer is the leading cause of death from a intestinal tract cancer in China.In most
cases, the high death rate is due to tumor that has spread beyond the gastric cancer at the
time of diagnosis. In China, the standard chemotherapy for the initial treatment of gastric
cancer is a combination of a platinum analogue with 5-Fu.With modern surgical interventions
and contemporary chemotherapy, most patients attain better clinical remission.The majority
of them, however, will eventually have a relapse and die of the disease.
The peritoneal cavity is the principal site of disease in gastric cancer.Although the
intensity of intravenous chemotherapy is limited mainly by myelotoxicity, several active
drugs can be administered directly into the peritoneal cavity. The rationale for
intraperitoneal therapy in gastric cancer is that the peritoneum, the predominant site of
tumor, receives sustained exposure to high concentrations of antitumor agents while normal
tissues, such as the bone marrow, are relatively spared.
The investigators conducted this trial to investigate the efficacy and safety of
intraperitoneal chemotherapy in advanced gastric cancer.
To investigate efficacy and safety of intraperitoneal chemotherapy as part of adjuvant treatment for advanced gastric cancer. ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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