Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT01015222 |
| Other study ID # |
2009-0521 |
| Secondary ID |
NCI-2012-01274 |
| Status |
Completed |
| Phase |
Phase 1
|
| First received |
|
| Last updated |
|
| Start date |
November 2009 |
| Est. completion date |
May 27, 2021 |
Study information
| Verified date |
November 2022 |
| Source |
M.D. Anderson Cancer Center |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
The goal of this clinical research study is to find the highest tolerable dose of the
combination of dasatinib, bevacizumab, and paclitaxel with or without Methylnaltrexone that
can be given to patients with advanced cancer. The safety of this drug combination will also
be studied.
Description:
The Study Drugs:
Dasatinib is designed to decrease the activity of one or more proteins that are responsible
for the uncontrolled growth of tumor cells. This may cause the tumor cells to die.
Bevacizumab is designed to block the growth of blood vessels that supply nutrients necessary
for tumor growth. This may prevent or slow down the growth of cancer cells.
Paclitaxel is designed to block cancer cells from dividing, which may cause them to die.
Methylnaltrexone is designed to block the constipating effect of opioid analgesics on the
gastrointestinal tract. It is also capable of blocking the growth of blood vessels that
supply nutrients necessary for tumor growth. This may prevent or slow down the growth of
cancer cells.
Study Groups:
Dose escalation:
If you are found to be eligible to take part in this study, you will be assigned to a dose
level of dasatinib, bevacizumab, and paclitaxel based on when you join this study. Up to 8
dose levels of dasatinib, bevacizumab, and paclitaxel will be tested. Three (3) to 9
participants will be enrolled at each dose level. The first group of participants will
receive the lowest dose level. Each new group will receive a higher dose than the group
before it, if no intolerable side effects were seen. This will continue until the highest
tolerable dose of the combination of dasatinib, bevacizumab, and paclitaxel is found.
The highest tolerable dose of the combination of dasatinib, bevacizumab, and paclitaxel that
was found will be given in combination with methylnaltrexone to up to 6 participants. If
intolerable side effects occur, the next group of up to 6 participants will receive a lower
dose of methylnaltrexone but the same dose of the combination of dasatinib, bevacizumab, and
paclitaxel.
Dose expansion:
Once the highest safe dose of the combinations of dasatinib, bevacizumab, and paclitaxel with
and without methylnaltrexone are found, 14 additional participants will be enrolled and
receive the study drugs at each dose level combination. Participants with a tumor type (14
for each tumor type) that have responded to the study drug combination will receive the study
drugs at that dose level, as well.
Study Drug Administration:
Each study "cycle" is 28 days.
Everyday, you will take dasatinib by mouth 1 time a day. You should take it at about the same
time each day with food and a cup of water (about 8 ounces).
On Days 1 and 15 of each cycle, you will receive bevacizumab by vein over 90 minutes. If the
first dose is well tolerated, you will receive the next dose over 60 minutes. If the second
dose is well tolerated, you will receive the next doses over 30 minutes.
On Days 1, 8, and 15 of each cycle, you will receive paclitaxel by vein over 60 minutes. On
Days 1 and 15, your paclitaxel dose will be given after your bevacizumab dose.
About 30 minutes before each scheduled dose of paclitaxel, you will also receive medications
(such as dexamethasone) to lower the likelihood of experiencing allergic reactions.
If you receive methylnaltrexone, you will receive it by injection under the skin either to
the upper arm, upper thigh, or stomach at the same time 2 times every day. The study doctor
or nurse will teach you how to give the injections yourself.
Study Visits:
At every study visit, you will be asked about any current health conditions you have, drugs
you may be taking, and if you have experienced any side effects.
Around Days 8 and 28 of Cycle 1:
- You will have a physical exam.
- Blood (about 2 teaspoons) will be drawn for routine tests.
Around Day 15 of Cycle 1, blood (about 2 teaspoons) will be drawn for routine tests.
Around Day 28 of Cycles 2 and beyond:
- You will have a physical exam.
- Blood (about 2 teaspoons) will be drawn for routine tests.
Every 4 weeks, you will have a blood (about 1 teaspoon) drawn or urine collected for
pregnancy test if you are able to become pregnant.
Every 8 weeks, you will have an x-ray, CT scan, MRI scan, and/or PET/CT scan to check the
status of the disease. If the study doctor thinks it is needed, they will be performed more
often.
Length of Study:
You may stay on study for as long as the disease does not get worse, you have not experienced
intolerable side effects, and if the study doctor thinks it is in your best interest.
End-of-Study Visit:
About 28 days after the last dose of study drugs, you will have an end-of-study visit. At
this visit, the following tests or procedures may be performed:
- You will have a physical exam, including measurement of your vital signs.
- Your performance status will be recorded.
- Blood (about 2 teaspoons) will be drawn for routine tests.
- If the doctor thinks it is needed, you will have an x-ray, CT scan, MRI scan, and/or
PET/CT scan to check the status of the disease.
This is an investigational study. Dasatinib is FDA approved and commercially available for
the treatment of chronic myeloid leukemia. Bevacizumab is FDA approved and commercially
available for the treatment of colorectal, breast, lung, and brain cancer. Paclitaxel is FDA
approved and commercially available for the treatment of breast, lung, and ovarian cancer and
Kaposi's sarcoma. Methylnaltrexone is FDA approved and commercially available for the
treatment of constipation in patients with advanced illness who are receiving palliative
care. The combination of these drugs when given to patients with advanced cancer is
investigational.
Up to 218 patients will take part in this study. All will be enrolled at MD Anderson.
