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Omic Technologies to Track Resistance to Palbociclib in Metastatic Breast Cancer — OMERIC  

Advanced Breast Cancer Clinical Trial

Official title:
Omic Technologies to Track Resistance to Palbociclib in Metastatic Breast Cancer (OMERIC): A Cohort Study

Clinical Trial Summary

This is a monocentric cohort study, prospective and interventional with minimal risks and constraints for advanced breast cancer. The planned interventions are collection of biological samples at different times. The study will aim to do a descriptive analysis of omics profiles evolution (tumor, volatile organic components) over time, before and after disease progression under Palbociclib treatment with a clinical-biological database.

Clinical Trial Description

Patients enrolled in the study will receive the following interventions: - Biospecimen sample collection: before and during treatment, and at progression - Tumor biopsy before treatment and at progression The aim of this study is to describe molecular changes associated with resistance to Palbociclib at the individual level and describe longitudinal changes in the profile of tumor, VOCs and exosomes according to treatment response. Other objectives of the study include: - Proportion of single or shared molecular alterations / signatures between patients at progression time - Associations between tumor signatures, VOCs and exosomes - Compare molecular changes identified by proteomics with those observed by genomics / transcriptomics - Compare the evolution of VOCs and exosomes over time with evolution of liquid biopsy markers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04653740
Study type Interventional
Source Centre Oscar Lambret
Contact Nawale NH HAJJAJI, MD, PhD
Phone 0320295910
Email promotion@o-lambret.fr
Status Recruiting
Phase N/A
Start date September 8, 2020
Completion date September 2023
View Details
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