Adults Clinical Trial
— OPEXOfficial title:
Impact of a Training Program on the Body Composition of Overweight and Obese Young Adults : Concentric Versus Eccentric Exercise
Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle wich permits
eccentric (ECC) lower limbs contractions at a defined power output. With this type of
ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the
same power output. Consequently, ECC program could be used in chronic disorders with limited
capacities, such as obesity.
The investigators hypothesis that an eccentric training program, as it will induce higher
mechanical constraints, would improve body composition, especially by reducing fat mass.
This effect could be explained by an increased rest energy expenditure and a better
improvement in biological parameters (particularly lipid profile and insulin-resistance)
after ECC training (versus CON training).
This study aims to compare the modification of fat mass after an ECC program versus a CON
program at the same VO2. The secondary goal is to assess the physiological mechanisms
involved in the modification of body composition
Status | Not yet recruiting |
Enrollment | 30 |
Est. completion date | January 2020 |
Est. primary completion date | December 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - - Adults - Obese (BMI>35) - Inactive (<10 METS/h/week) - No other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no contraindication to physical activity Exclusion Criteria: - (BMI<35) |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject)
Country | Name | City | State |
---|---|---|---|
France | CHU Clermont-Ferrand | Clermont-Ferrand |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Clermont-Ferrand |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | change in total body fat mass (Dual X ray Absorptiometry) | before and after the 12 weeks training program | Yes | |
Secondary | aerobic capacities (VO2max) | before and after the 12 weeks training program | Yes | |
Secondary | isometric muscular lower limbs strength | before and after the 12 weeks training program | Yes | |
Secondary | isokinetic muscular lower limbs strength | before and after the 12 weeks training program | Yes | |
Secondary | rest energy expenditure (indirect calorimetry) | before and after the 12 weeks training program | Yes | |
Secondary | biological parameters (plasma lipid profile) | before and after the 12 weeks training program | Yes | |
Secondary | biological parameters (insulin-resistance) | before and after the 12 weeks training program | Yes | |
Secondary | physical activity | (questionnaires) | before and after the 12 weeks training program | Yes |
Secondary | physical activity | (actimetry) | before and after the 12 weeks training program | Yes |
Secondary | food intakes | (measurements) | before and after the 12 weeks training program | Yes |
Secondary | food intakes | (questionnaires) | before and after the 12 weeks training program | Yes |
Secondary | quality of life (questionnaires) | before and after the 12 weeks training program | Yes | |
Secondary | segmental body composition | (segmental fat and fat free mass) | before and after the 12 weeks training program | Yes |
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