Adult Hepatocellular Carcinoma Clinical Trial
Official title:
Genomic and Imaging Study for Patients Undergoing Surgery for Liver Cancer
This clinical trial studies positron emission tomography (PET)/computed tomography (CT) in diagnosing patients with liver cancer undergoing surgical resection. Diagnostic procedures, such as fluorine-18 fluoromethylcholine PET/CT, may help find and diagnose liver cancer.
PRIMARY OBJECTIVES:
I. Determine the most optimal fluorine-18 (18F) fluoromethylcholine (FCH) PET/CT parameters
for detecting primary hepatocellular carcinoma (HCC) by conducting a clinical
radiologic-pathologic correlation study to estimate and compare the receiver operating
characteristics of kinetic and static PET measures of tumor FCH metabolism in patients that
test positive during screening or conventional imaging.
II. Identify cancer signaling pathways associated with choline metabolism in HCC by profiling
the global gene expression patterns in fresh-frozen liver tissue samples that are correlated
with the features derived from FCH PET/CT images.
III. Characterize the association between features derived from FCH PET/CT images of the
liver and clinical liver disease severity and comparatively evaluate the ability of
corresponding gene expression signatures to predictively model HCC disease outcome.
OUTLINE:
Patients undergo 18F-fluoromethylcholine PET/CT within 14 days of surgical resection.
After completion of study treatment, patients are followed up periodically.
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