Early Diagnosis Of Childhood Cerebral ALD

Status Withdrawn

Clinical Trial Summary

The goal of this single institution study is to evaluate boys with adrenoleukodystrophy (ALD) diagnosed early in life, and to prospectively monitor them to determine parameters that will facilitate earlier detection of the childhood cerebral form of the disease. These at-risk subjects will be assessed yearly through travel to the University of Minnesota, where plasma and cerebral spinal fluid (CSF) biomarker studies, MRI based imaging and neuropsychological assessments will be performed at the University of Minnesota Masonic Children's Hospital and Clinics. The MRI and lumbar puncture to obtain CSF will be obtained under sedation. In addition, at intervening 6 months intervals information will be obtained remotely, including surveys and MRI's in their home location. Also at that time blood samples will be obtained locally and shipped to the University of Minnesota for study. There is no therapeutic intent in this study.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Adrenoleukodystrophy

Clinical Trial Details

NCT number	NCT02948062
Study type	Observational
Source	Masonic Cancer Center, University of Minnesota
Contact
Status	Withdrawn
Phase
Start date	November 2018
Completion date	July 2023

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