Effect of Glycerol Trierucate on Clinical Course of Adrenoleukodystrophy

Status Terminated

Clinical Trial Summary

OBJECTIVES: I. Evaluate the clinical efficacy of combination glyceryl trierucate and glyceryl trioleate (Lorenzo's Oil) therapy in boys with X-linked adrenoleukodystrophy. II. Compare the frequency and severity of neurological disability of study patients with untreated historical controls.

Clinical Trial Description

PROTOCOL OUTLINE: This is an open label study. Patients must follow dietary instructions as provided by the investigator. Patients receive 2-4 tablespoons of a mixture of glyceryl trierucate and glyceryl trioleate oil once daily. Patients complete a neuropsychological scoring scale questionnaire to measure neurological disability. Patients undergo physical examinations including magnetic resonance imaging and magnetic resonance spectroscopy of the head. Patients are followed monthly for 6 months, then every 3 months until they reach the age of 13 years or death. ;

Study Design

Related Conditions & MeSH terms

Adrenoleukodystrophy

Clinical Trial Details

NCT number	NCT00004418
Study type	Interventional
Source	Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Contact
Status	Terminated
Phase	Phase 2
Start date	April 1998
Completion date	December 2014

View Details

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