Phase 1 Study of 68Ga-R8760

Adrenocortical Carcinoma Clinical Trial

Official title:

Phase 1 Safety and Dosimetry Study of 68Ga-R8760 in Patients With Adrenocortical Carcinoma and Healthy Volunteers

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05999292
• Other study ID #: R8760-101
• Status: Recruiting
• Phase: Phase 1
• Start date: September 11, 2023
• Est. completion date: April 2024

Study information

• Verified date: October 2023
• Source: Radionetics Oncology
• Contact: Istvan Molnar, MD
• Phone: 201-912-6062
• Email: imolnar[@]radionetics.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A Phase 1 Safety and Dosimetry Study of 68Ga-R8760 in Patients with Adrenocortical Carcinoma and Healthy Volunteers

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 25
• Est. completion date: April 2024
• Est. primary completion date: April 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Adrenocortical Carcinoma Subjects

Inclusion Criteria:

1. Pathologically confirmed ACC.

2. Newly diagnosed or recurrent/relapsed ACC with at least 1 measurable target lesion per RECIST v1.1 criteria.

3. Male or non-pregnant, non-lactating female subjects age =18 years.

4. Female subjects of childbearing potential and male subjects (if sexually active) must agree to use adequate method(s) of effective contraception during their participation in the study.

5. Eastern Cooperative Oncology Group (ECOG) Performance Status =2.

6. Adequate hepatic function as defined below:

1. Serum alanine aminotransaminase (ALT)/ aspartate aminotransaminase (AST) =3 × upper limit of normal (ULN) or =5 × ULN if liver metastases are present or received prior mitotane therapy, and

2. Serum bilirubin - total =1.5 × ULN (unless due to Gilbert's syndrome or hemolysis in which case total =3.0 × ULN).

7. Adequate renal function as measured by creatinine clearance calculated by the Cockcroft-Gault formula (=60 mL/minute).

8. Able to understand and willing to sign a written informed consent form.

Exclusion Criteria:

1. Administered a radionuclide within a period of time corresponding to less than 10 physical half-lives of the radionuclide prior to study Day 1.

2. Radiotherapy =14 days prior to study Day 1.

3. Major surgery =21 days prior to study Day 1 or has not recovered from adverse effects of such procedure.

4. Severe or unstable medical condition, such as congestive heart failure (New York Heart Association [NYHA] Class III or IV), ischemic heart disease, uncontrolled hypertension, uncontrolled diabetes mellitus, as well as an uncontrolled cardiac arrhythmia requiring medication (=Grade 2, according to NCI-CTCAE Version 5.0), myocardial infarction within 6 months prior to starting study drug, or any other significant or unstable concurrent cardiac illness. Note: Stable chronic atrial fibrillation is allowed.

5. Congenital long QT syndrome or corrected QT interval by Fridericia (QTcF) interval >450 msec (males) or >470 msec (females).

6. History of cerebrovascular accident within 6 months or that resulted in ongoing neurologic instability.

7. History of other previous or concurrent cancer that would interfere with the determination of safety.

8. Major active infection requiring antibiotics.

9. Known active human immunodeficiency virus infection or active infection with Hepatitis B or C.

10. Acute illness within 14 days prior to study Day 1unless mild in severity, as assessed by the Investigator.

11. Any other condition that in the opinion of the Investigator would place the subject at an unacceptable risk or cause the subject to be unlikely to fully participate or comply with study procedures.

Healthy Volunteers

Inclusion Criteria:

1. Healthy male or non-pregnant, non-lactating female subjects aged between 18 and 59 years (inclusive).

2. Female subjects of childbearing potential and male subjects (if sexually active) must agree to use adequate method(s) of effective contraception during their participation in the study.

3. Body mass index between 18.0 and 32.0 kg/m2 (inclusive).

4. Adequate renal function as measured by creatinine clearance calculated at =60 mL/minute by the Cockcroft-Gault formula.

5. Able to understand and willing to sign a written informed consent form.

Exclusion Criteria:

1. Prior unilateral or bilateral adrenalectomy.

2. Mental or legal incapacitation.

3. History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance, unless approved by the Investigator (or designee).

4. Subjects diagnosed with adrenal disease, including Cushing's syndrome, adrenal insufficiency, or congenital adrenal hyperplasia.

5. Glucocorticoid steroid use (including topical) within 4 weeks prior to study Day 1 (inhaled steroids are allowed).

6. Active or recent (within 30 days of screening) infection or history of recurrent chronic infections with underlying condition that may predispose one to infections.

7. Resting pulse rate =100 or <40 beats per minute at screening. If abnormal, a repeat measurement will be conducted to confirm.

8. Systolic blood pressure >160 or <90 mmHg or diastolic blood pressure >90 or <50 mmHg, unless judged by the Investigator to have no clinical significance.

9. Participation in a clinical study involving administration of an investigational drug in the past 30 days or 5 half-lives (whichever is longer) prior to study Day 1.

10. Administered a radionuclide within a period of time corresponding to less than 10 physical half-lives of the radionuclide prior to study Day 1.

11. Donation of blood or significant blood loss within 3 months prior to screening, donation of plasma within 2 weeks prior to screening, or donation of platelets within 6 weeks prior to screening.

Related Conditions & MeSH terms

• Adrenocortical Carcinoma
• Carcinoma

Intervention

Drug:
• 68Ga-R8760 injection at pre-defined dose levels
PET/CT imaging at predefined timepoints
• 68Ga-R8760 injection
PET/CT imaging at a single timepoint

Locations

Country	Name	City	State
United States	University of Michigan Nuclear Medicine	Ann Arbor	Michigan
United States	MD Anderson Cancer Center	Houston	Texas

Sponsors (1)

Lead Sponsor	Collaborator
Radionetics Oncology

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of adverse events characterized overall and by type, frequency, seriousness, relationship to study drug, timing and severity graded according to the NCI-CTCAE v5.0; absolute values and changes in clinical laboratory parameters		7 days
Primary	Absorbed dose coefficients (mGy/MBq) in target organs and the effective dose coefficient (mSv/MBq)		1 day
Secondary	Number and location of tumors identified by 68Ga-R8760 PET/CT and by anatomic images		1 day
Secondary	Maximum standard uptake value (SUVmax) of each tumor and of source organ		1 day
Secondary	Ratio of the tumor SUV over reference region SUV		1 day
Secondary	Area under the plasma concentration versus time curse (AUC)		1 day
Secondary	Maximum plasma concentration (Cmax)		1 day
Secondary	Half-life (T1/2) of 68Ga-R8760		1 day