| Eligibility |
Inclusion Criteria:
1. Male/female participants who are at least 19 years of age on the day of signing
informed consent with histologically confirmed diagnosis of adrenal cortical carcinoma
will be enrolled in this study.
2. Patients with locally advanced, recurrent, or metastatic disease not amenable to
surgery, radiotherapy, or combined modality therapy with curative intent.
3. Patients who have received prior systemic therapy including combined mitotane and
cisplatin-based chemotherapy as a palliative aim systemic therapy in advanced setting,
and have had disease progression within 6 months of the last dose of the most recent
systemic therapy. Patients who discontinued prior therapy due to intolerable
toxicities can be included.
4. Patients should have measurable disease according to RECIST v1.1 meeting the following
criteria:
1. at least 1 lesion of =10 mm in the longest diameter for a non-lymph node or =15
mm in the short-axis diameter for a lymph node that is serially measurable
according to RECIST using CT or MRI
2. lesions that have had external beam radiotherapy or other loco-regoinal therapies
such as radiofrequency ablastion must show subsequent evidence of substantial
size increase to be deemed a target lesion.
5. Subject must have an Eastern Cooperative Oncology Group (ECOG) performance status (PS)
0 to 1
6. Adequately controlled blood pressure (BP) with or without antihypertensive
medications, defined as BP=150/90 mmHg at screening and no change in hypertensive
medications within 1 week prior to the cycle 1 day 1.
7. Adequate renal function defined as creatinine =1.5 times the upper limit of normal
(×ULN) or calculated creatinine clearance =30 ml/min per the Cockcroft and Gault
formula
8. Adequate bone marrow function:
1. Absolute neutrophil count (ANC)=1500/mm3 (=1.5×103/µL)
2. platelets=100,000/ mm3 (=100×109/L)
3. hemoglobin=9.0 g/dL
9. adequate blood coagulation function defined by international Normlized Ratio (INR)=1.5
unless participant is receiving anticoagulation therapy
10. adequate liver function defined by:
1. total bilirubin =1.5×ULN except for unconjugated hyperbilirubinemia of Gilbert's
syndrome
2. alkaline phosphatase (ALP), alanine aminotransferase (ALT), and asparate
aminotransferase (AST)=3×ULN (in the case of liver metastases =5×ULN), unless
there are bone metastases. Subject with ALP values >3×ULN and known to have bone
metastases can be included.
11. Life expectancy more than 3 months
12. Patients should agree to discontinue mitotane
13. Females of childbearing potential must agree to use a highly effective method of
contraception for the entire study period and for 120 days after study discontinuation
(see appendix 7)
14. Male participants who are partners of women of childbearing potential must use a
condom plus spermicide and their female partners if of childbearing potential must use
a highly effective method of contraception (see inclusion criterion #14 and appendix
7) beginning at least 1 mentrual cycle prior to starting study drugs, throughout the
entire study period, and for 120 days after the last dose of study drug, unless the
male subjects are totally sexually abstinent or have undergone a successful vasectomy
with confirmed azoospermia or unless the female partners have been sterilized
surgically or are otherwise proven sterile.
15. Have provided archival tumor tissue sample or newly obtained core or excisional biopsy
of a tumor lesion not previously irradiated for biomarker analysis. Formalin-fixed,
paraffin embedded (FFPE) tissue blocks are preferred to slides. Newly obtained
biopsies are preferred to archived tissue. In the case of archival tissue cannot be
provided, patients with inaccessible tumors for biopsy specimens or patients who
refuse to be biopsied can be enrolled without a biopsy at the discretion of treating
physician.
16. Voluntary agreement to provide written informed consent and the willingness and
ability to comply with all aspects of the protocol.
Exclusion Criteria:
1. Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti PD L2 agent or with
an agent directed to another stimulatory or co-inhibitory T-cell receptor (eg, CTLA-4,
OX 40, CD137).
2. Has received prior therapy with any VEGFR TKI or monoclonal antibody targeting VEGF
pathway.
3. Has received major surgery within 2 weeks of start of study intervention. Participants
must have recovered from any toxicity and/or complications from major surgery prior to
starting therapy.
4. Previous radiotherapy to the only measurable lesion: but previous radiotherapy will be
permitted unless the lesion is the only measurable lesion.
5. Subjects having >1+ proteinuria on urinalysis will undergo 24-hour urine collection
for quantitative assessment of proteinuria. Subjects with urine protein =1g/24-hour
will be ineligible.
6. Gastrointestinal malabsorption, gastrointestinal obstruction, or any other condition
that might affect the absorption of lenvatinib.
7. Significant cardiovascular impairment within 6 months of the first dose of study drug.
History of congestive heart failure greater than New York Heart Association (NYHA)
Class II, unstable angina, myocardial infarction or stroke, cardiac arrhythmia
associated with significant cardiovascular impairment, or a left ventricular ejection
fracture (LVEF) below the institutional normal range as determined by MUGA or
echocardiogram.
8. Prolongation of QTc interval to >480 msec
9. Bleeding or thrombotic disorders or subjects at risk for severe hemorrhage. The degree
of tumor invasion/infiltration of major blood vessels should be considered because of
the potential risk of severe hemorrhage associated with tumor shrinkage/necrosis
following lenvatinib therapy.
10. Has received a live vaccine within 30 days prior to the first dose of study drug.
Examples of live vaccines include, but are not limited to, the following: measles,
mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus
Calmette-Guérin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection
are generally killed virus vaccines and are allowed; however, intranasal influenza
vaccines (eg, FluMist®) are live attenuated vaccines and are not allowed.
11. Is currently participating in or has participated in a study of an investigational
agent or has used an investigational device within 4 weeks prior to the first dose of
study intervention.
12. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
(in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
immunosuppressive therapy within 7 days prior to the first dose of study drug. The use
of physiologic doses of corticosteroids may be approved at the discretion of treating
physician. In mitotane treated subject, adrenal insufficiency happens inevitably and
required dose of corticosteroid is higher than usual due to altered metabolism of
corticosteroid.48 Therefore, the decision on whether the dose of maintenance
corticosteroid is acceptable for enrollment depends on investigator.
13. Has a known additional malignancy that is progressing or has required active treatment
within the past 2 years. Participants with basal cell carcinoma of the skin, squamous
cell carcinoma of the skin, or carcinoma in situ (eg, breast carcinoma, cervical
cancer in situ) that have undergone potentially curative therapy are not excluded.
Clinically insignificant or curatively treated localized prostate cancer and
curatively treated thyroid cancer of any stage can be included at the discretion of
treating physician.
14. Has known active CNS metastases and/or carcinomatous meningitis. Participants with
previously treated brain metastases may participate provided they are radiologically
stable, i.e. without evidence of progression for at least 4 weeks by repeat imaging
(note that the repeat imaging should be performed during study screening), clinically
stable and without requirement of steroid treatment for at least 14 days prior to
first dose of study intervention.
15. Has active autoimmune disease that has required systemic treatment in the past 2 years
(i.e. with use of disease modifying agents, corticosteroids or immunosuppressive
drugs). Replacement therapy (eg., thyroxine, insulin, or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a
form of systemic treatment and is allowed.
16. Has a history of (non-infectious) pneumonitis that required steroids or has current
pneumonitis. Non-infectious pneumonitis include, but not limited to, idiopathic
pulmonary fibrosis, organizing pneumonia, or drug-induced pneumonitis. History of
radiation pneumonitis in the radiation field is permitted.
17. Has a known history of Hepatitis B (defined as Hepatitis B surface antigen [HBsAg]
reactive) or known active Hepatitis C virus (defined as HCV RNA [qualitative] is
detected) infection. Note: no testing for Hepatitis B and Hepatitis C is required
unless mandated by local health authority.
18. Has an active tuberculosis. However, inactive tuberculosis (previously treated or
latent infection without evidence of active disease) is allowed.
19. Has a known history of Human Immunodeficiency Virus (HIV) infection.
20. Has a history or current evidence of any condition, therapy, or laboratory abnormality
that might confound the results of the study, interfere with the participant's
participation for the full duration of the study, or is not in the best interest of
the participant to participate, in the opinion of the treating investigator.
21. Has known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the trial.
22. All females with child-bearing capacity who has a positive urine pregnancy test within
72 hours prior to the first dose of study drug. If the urine test is positive or
cannot be confirmed as negative, a serum pregnancy test will be required.
23. Is pregnant or breastfeeding or expecting to conceive or father children within the
projected duration of the study, starting with the screening visit through 120 days
after the last dose of trial treatment.
24. Has had an allogenic tissue/solid organ transplant.
25. Serious nonhealing wound, ulcer, or bone fracture.
26. Has active infections that requires systemic therapy.
27. Has the side effect by previous treatment that has not recovered to baseline or below
G1.
28. Has a known severe hypersensitivity reaction history of humanized monoclonal
antibodies or VFGFR TKI including ingredients used in medication.
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