Adrenocortical Carcinoma Clinical Trial
Official title:
Evaluation of Suramin in Advanced Adrenal Cortical Carcinoma, Phase II
RATIONALE: Some tumors need growth factors produced by the body to keep growing. Suramin may
interfere with the growth factor and stop the tumor from growing.
PURPOSE: Phase II trial to study the effectiveness of suramin in treating patients with
stage III or stage IV adrenocortical cancer.
OBJECTIVES: I. Assess the response of patients with adrenocortical carcinoma treated with
suramin. II. Evaluate the qualitative and quantitative toxic effects of this therapy.
OUTLINE: Patients are described according to stage, performance status, prior radiotherapy,
prior surgery, and prior mitotane therapy. Patients receive suramin IV for 5 days in the
first week, then twice a week for 2 weeks, and then weekly for a total of 12 weeks.
Hydrocortisone is taken PO twice daily. Following a 12 week rest, patients receive a second
course; those with stable or responding disease continue treatment for a maximum of four
courses.
PROJECTED ACCRUAL: A maximum of 40 patients will be accrued at a rate of 6-7 per year.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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