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Treating PCOS With Semaglutide vs Active Lifestyle Intervention — TEAL  

NAFLD Clinical Trial

Official title:
Treating PCOS With Semaglutide vs Active Lifestyle Intervention

Clinical Trial Summary

Girls with obesity and polycystic ovarian syndrome will receive either glucagon like peptide-1 receptor agonist therapy or a dietary intervention for 12 weeks to decrease the metabolic syndrome, in particular to lower hepatic fat and improve insulin sensitivity.

Clinical Trial Description

In obese girls with polycystic ovarian syndrome, testosterone and obesity combine to create unique pathology to increase metabolic disease including fatty liver and insulin resistance, which may be mediated by altered glucagon like peptide-1 activity. The investigators will treat girls with obesity and polycystic ovarian syndrome for 4 months with a glucagon like peptide-1 receptor agonist compared to dietary intervention to primarily lower hepatic fat and secondarily improve whole body and adipose insulin sensitivity. Mechanisms of hepatic metabolism, including rates of de novo lipogenesis and relative mitochondrial flux will also be assessed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03919929
Study type Interventional
Source University of Colorado, Denver
Contact
Status Active, not recruiting
Phase Phase 2/Phase 3
Start date May 3, 2019
Completion date July 2024
View Details
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