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The Role of Oxytocin-receptor Signalling in Physiological Regulation of Eating Behaviour in Individuals With Obesity — FOxy  

Adiposity Clinical Trial

Official title:
The Role of Oxytocin-receptor Signalling in Physiological Regulation of Eating Behaviour in Individuals With Obesity

Clinical Trial Summary

The present study evaluates appetite, glucose metabolism, gastrointestinal motility and energy expenditure in men and women with obesity (BMI 30-40 kg/m2) under oxytocin exposure compared to placebo.

Clinical Trial Description

In a randomised, double-blind, placebo-controlled, crossover fashion, 24 participants will complete two experimental days (A and B) including a mixed meal test and an ad libitum meal test. The procedures during the two experimental days are similar except for intravenous infusion of oxytocin on experimental day A and placebo (saline) on experimental day B, respectively. On experimental days, oxytocin or placebo infusion will be started at timepoint -60 minutes. At timepoint 0 minutes, participants will ingest a liquid mixed meal. After 190 minutes, participants are served an ad libitum meal followed by ad libitum snacks. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06189001
Study type Interventional
Source University Hospital, Gentofte, Copenhagen
Contact Ida Marie Gether, MD
Phone 004524246625
Email ida.marie.gether.01@regionh.dk
Status Recruiting
Phase N/A
Start date January 1, 2024
Completion date December 31, 2024
View Details
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