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Clinical Trial Summary

This is an 8 to14-week three-arm randomized controlled in children 8 to 12 years old. The main purpose of the study is to evaluate if stevia (as with other sweeteners and consistent with prior research in children and adults) has benefits for weight control and metabolic function relative to caloric sweeteners, and whether it provides benefits in this regard similar to water.


Clinical Trial Description

The proposed study will be an 8 to14-week three-arm randomized controlled blinded trial in children ages 8 to12 years from the Central, Arkansas region. Children with normal weight (BMI percentile <85th, n = 90) and excessive weight (BMI percentile ≥85th and <140% of the 95th, n =120) will consume either: 1. Sucrose-sweetened beverage 2. Stevia-sweetened beverage 3. Calorie free flavored water beverage Participants with excessive weight will complete a 14-week intervention to assess both primary and secondary hypotheses. In parallel, normal weight participants will be enrolled with the objective of monitoring indicators of safety for steviol consumption through assessment of changes in metabolic function (glucoregulation and cardiometabolic) markers as well as assessment of shifts in gut microbial communities and steviol metabolism over 8 weeks ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05992688
Study type Interventional
Source Arkansas Children's Hospital Research Institute
Contact Eva C Diaz, M.D.
Phone 5013643056
Email ecdiazfuentes@uams.edu
Status Recruiting
Phase N/A
Start date September 19, 2023
Completion date October 31, 2026

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