Clinical Trials Logo

Adipose Tissue, Brown clinical trials

View clinical trials related to Adipose Tissue, Brown.

Filter by:
  • None
  • Page 1

NCT ID: NCT04352244 Recruiting - Obesity Clinical Trials

The Physiology of Human Brown Adipose Tissue

Start date: March 5, 2020
Phase:
Study type: Observational

Brown fat is a type of fat, found in both children and adults, which can produce heat and regulate the body's metabolism and energy use. White fat is the more common type of fat which is used to store extra calories. Understanding more about differences between brown and white fat may allow us to develop new approaches to improve the body's metabolism.

NCT ID: NCT03541096 Active, not recruiting - Obesity Clinical Trials

Winter-Swimming and Brown Adipose Tissue Activity in Middel-aged Obese Subjects (WinterBAT).

WinterBAT
Start date: November 7, 2018
Phase: N/A
Study type: Interventional

This study investigates repetitive cold-water exposure on brown fat activity assessed by PET/CT scanning. Furthermore we will assess glucose control upon winter-swimming. Obese prediabetic men and women will be randomized to winter-swimming or control conditions for 4 months.

NCT ID: NCT03189511 Completed - Insulin Resistance Clinical Trials

Effect of Fluvastatin on Brown Fat Activity

FluvaBAT
Start date: May 31, 2017
Phase: Phase 4
Study type: Interventional

The purpose of this study is to elucidate the effects of Fluvastatin on brown adipose tissue activity in humans.

NCT ID: NCT03111719 Recruiting - Obesity Clinical Trials

Human Brown Adipose Tissue and Mitochondrial Respiration

Start date: January 4, 2010
Phase:
Study type: Observational

This study is focused on measuring mitochondrial activity of human brown adipose tissue. During surgery, adipose tissue biopsies from white and brown adipose tissue will be collected from the deep neck area. These biopsies will be used to examine mitochondrial function via histological analysis, biochemical analysis and in vitro experiments based on precursor cells present in the biopsies.

NCT ID: NCT03096535 Completed - Obesity Clinical Trials

Cold Induced Activation of Brown Adipose Tissue in Humans

COLDBAT
Start date: April 2, 2017
Phase: N/A
Study type: Interventional

This study investigates cold-induced brown fat activation assessed using PET/MR scans. Subjects will participate in an acute cooling intervention day and a thermoneutral intervention day with PET/MR scans on both days. A secondary purpose is to make a validation of an infrared thermography camera by comparison of skin temperatures and SUV of the supraclavicular brown adipose tissue.

NCT ID: NCT02790255 Completed - Obesity Clinical Trials

BRown Fat Activity Measurement With Infrared imaginG tHermography andThermogenesis - the BRIGHT Study

BRIGHT
Start date: November 2014
Phase: N/A
Study type: Interventional

The whole body calorimeter is sensitive enough to reliably measure cold-induced thermogenesis as a surrogate marker of brown adipose tissue (BAT) activation. The infrared (IR) energy flux from activated BAT can be accurately imaged and quantified using an IR imaging device, and that this IR energy output may be correlated to the increased energy expenditure quantified by the whole body calorimeter.

NCT ID: NCT02291458 Recruiting - Glucose Intolerance Clinical Trials

L-arginine and Brown Adipose Tissue

ArgMB
Start date: November 2014
Phase: Phase 3
Study type: Interventional

The South Asian population is facing an epidemic of type 2 diabetes, of which the underlying cause is still unknown. It is currently hypothesized that an ethnic susceptibility towards a disturbed energy metabolism may underlie this disadvantageous metabolic phenotype. In line with this, the investigators recently discovered that Dutch South Asian subjects have 32% lower resting energy expenditure (REE) and 34% lower energy-combusting brown adipose tissue (BAT) compared to matched white Caucasians. Nitric oxide (NO) was recently shown to be crucial for BAT development and, interestingly, South Asians have diminished NO bioavailability. Thus, the disadvantageous metabolic phenotype in South Asians may be caused by diminished NO bioavailability resulting in lower BAT volume. Therefore, the investigators hypothesize that increasing NO generation in the body by administration of L-arginine, the precursor of NO, will improve their metabolic phenotype by increasing BAT volume, thereby increasing REE and clearance of triglycerides and glucose by BAT. To investigate this, the investigators will perform a randomized placebo-controlled multicenter cross-over study in moderately obese Dutch South Asians and matched white Caucasians. Subjects will receive L-arginine (9 gram/day) or placebo for 6 weeks, followed by a wash-out period of 4 weeks and then again 6 weeks of one of either treatments. At the end of both treatment periods, a cold-induced PET-CT scan will be performed. Furthermore, muscle and fat biopsies will be obtained and thermoregulation will be assessed.