Control Clinical Trial
Official title:
Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)
The purpose of this study is to determine the relationship between the levels of Ribonucleic acid (RNA) circulating molecules, including ones in extracellular vesicles from different organs in the blood and in the saliva of patients with Acute Decompensated Heart Failure (ADHF) and Chronic Heart Failure (CHF) to see if a new, non-invasive diagnostic test can be developed for heart failure exacerbation.
The primary objective of this study is to investigate the expression of extracellular vesicle RNAs (evRNAs) during admission for and decongestion of ADHF patients and determine their diagnostic and prognostic potential. The main hypothesis is that these evRNAs are dynamically regulated in response to volume status changes. Thus, the aim is to delineate: i) the utility of salivary evRNA expression in discriminating ADHF from compensated chronic heart failure states in ADHF patients, chronic heart failure patients and controls (n=30 each); and ii) assess changes in expression in ADHF patients during decongestion. Plasma and salivary evRNA levels will be correlated to determine accuracy of salivary Extracellular Vesicles (EVs) to reflect changes in plasma. This is a multi-cohort study that will make use of clinical saliva and plasma samples of 90 subjects across three groups. The first group will consist of 30 patients admitted to the hospital for ADHF (clinical samples will be collected during acute decompensation and after diuresis of ADHF patients). The second group will consist of 30 patients with chronic heart failure who are seen in the outpatient clinic. The control group will also include 30 Supraventricular Tachycardia (SVT) patients recruited through the Electrophysiology Lab (EP). For each group, blood plasma and saliva samples will be obtained. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03216213 -
Evaluating Attitudes Towards Organ Donation in Singapore
|
N/A | |
| Completed |
NCT01571258 -
Text4Diet: A Text Messaging Program for Weight Loss
|
N/A | |
| Recruiting |
NCT03912597 -
VR-assisted Curriculum on Depression for Stigma Reduction
|
N/A | |
| Completed |
NCT00164528 -
Intervening With Children/Adolescents With FAS/ARND
|
Phase 1/Phase 2 | |
| Completed |
NCT00164307 -
Assisting Children With Prenatal Alcohol Exposure in Developing Peer Friendships
|
Phase 1/Phase 2 | |
| Completed |
NCT03238300 -
Neuroscience-Informed Treatment Development for Adolescent Alcohol Use
|
Phase 2 | |
| Completed |
NCT03602248 -
Speed Endurance Training, Muscle Damage and Performance in Soccer Players
|
N/A | |
| Completed |
NCT06197464 -
FLOAT Through Anxiety: Virtual Reality Application's Efficacy as a Tool to Distract From Negative Emotions and Thoughts
|
N/A | |
| Completed |
NCT06242548 -
How Type I Diabetes Responds to Different Diets (Normoglucidic or Ketogenic) During Physical Activity at Altitude
|
N/A | |
| Recruiting |
NCT05517811 -
Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing Surgical Resection
|
||
| Recruiting |
NCT05337410 -
Youth Empowerment Solutions: Engaging Youth for Anti Racism and Cultural Equity
|
N/A | |
| Recruiting |
NCT05321342 -
Coaching Teachers in Bullying Detection and Intervention
|
N/A | |
| Completed |
NCT02082145 -
Electrical Stimulation in Diabetic Peripheral Neuropathy
|
N/A | |
| Recruiting |
NCT06264011 -
Discrimination and Religious Experiences of Adult Muslimahs in Salaat
|
N/A | |
| Not yet recruiting |
NCT06116292 -
Impact of the Implementation of a Telemedicine Program on Patients Diagnosed With Asthma
|
N/A | |
| Completed |
NCT04557566 -
ED Recovery Course Online RCT
|
N/A | |
| Completed |
NCT00856726 -
Racial Differences in Phosphorus Metabolism
|
N/A | |
| Completed |
NCT03476200 -
Efficacy of Cognitive Behavioral Therapy and Hair Cortisol Concentration
|
N/A | |
| Withdrawn |
NCT05559944 -
Brief Writing Programs for Sexual Minority Young Adults in Alabama
|
N/A | |
| Completed |
NCT02128737 -
Neurobehavioral Effects of Partial Sleep Deprivation
|
N/A |