Adenoid Cystic Carcinoma Clinical Trial
Official title:
A Phase II Trial of All-trans Retinoic Acid (ATRA) in Advanced Adenoid Cystic Carcinoma
This research is studying how safe and effective all-trans retinoic acid (ATRA), is to treat advanced adenoid cystic carcinoma (ACC).
This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational drug to learn whether the drug works in treating a specific disease. "Investigational" means that the drug is being studied. The U.S. Food and Drug Administration (FDA) has not approved all-trans retinoic acid (ATRA) for this specific disease but it has been approved for other uses. The main purpose of this study is to see how effective all-trans retinoic acid (ATRA) is in treating tumor. Other reasons for conducting the study are: - To determine for how long all-trans retinoic acid (ATRA) may reduce the size or slow down the growth of tumor - To evaluate levels of circulating tumor DNA (ctDNA) released in the bloodstream as an indication of the disease activity - To better understand mechanisms of tumor resistance to ATRA ;
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