Compassionate Use of Brontictuzumab for Adenoid Cystic Carcinoma (ACC)

Status Completed

Clinical Trial Summary

The goal of this study is to start treatment with the NOTCH1 inhibitor brontictuzumab in an attempt to control tumors and prolong survival. The therapy involves participant being given the drug brontictuzumab to treat adenoid cystic carcinoma (ACC) with NOTCH 1 mutations. This is considered an investigational treatment.

Clinical Trial Description

Treatment:

Participant will receive brontictuzumab by vein over 30 minutes one time every 3 weeks.

Clinic Visits:

On Day 1 of Cycle 1 and then every 3 weeks from then on:

- Participant will have a physical exam

- Blood (about 3 teaspoons) will be drawn for routine tests.

Every 6 weeks, participant will have an MRI and CT scan to check the status of the disease.

Length of Treatment:

Participant may continue taking brontictuzumab for as long as the doctor thinks it is in their best interest. Participant will no longer be able to take the drug if the disease gets worse, they develop another illness that prevents receiving more treatment, or if intolerable side effects occur.

Brontictuzumab is not FDA approved or commercially available. It is currently being used for research purposes only. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02662608
Study type	Interventional
Source	M.D. Anderson Cancer Center
Contact
Status	Completed
Phase	N/A
Start date	December 29, 2015
Completion date	March 6, 2016

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04973683` - AL101 Before Surgery for the Treatment of Notch Activated Adenoid Cystic Cancer	Phase 1
Completed	`NCT01417143` - Dovitinib in Adenoid Cystic Carcinoma	Phase 2
Recruiting	`NCT04140526` - Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC	Phase 1/Phase 2
Active, not recruiting	`NCT05010629` - 9-ING-41 Plus Carboplatin in Salivary Gland Carcinoma	Phase 2
Recruiting	`NCT04801264` - Diagnosis of Adenoid Cystic Carcinoma on 68Ga-PSMA-617 PET-CT and Therapy With 177Lu-EB-PSMA-617	Early Phase 1
Completed	`NCT03319641` - PSMA-PET Imaging for Advanced ACC/SDC	N/A
Recruiting	`NCT02942693` - Trail Evaluating Particle Therapy With or Without Apatinib for H&N Adenoid Cystic Carcinoma	Phase 2
Completed	`NCT00581360` - Phase II Trial of Doxorubicin and Bortezomib in Patients With Incurable Adenoid Cystic Carcinoma of the Head and Neck	Phase 2
Not yet recruiting	`NCT05553782` - Drug Screening Using Novel IMD in ACC and Salivary Cancers	Early Phase 1
Completed	`NCT04291300` - Lutetium-177-PSMA Radioligand Therapy in Advanced Salivary Gland Cancer Patients	Phase 2
Active, not recruiting	`NCT02775370` - A Study of Apatinib in Recurrent/Metastatic Adenoid Cystic Carcinoma of the Head and Neck	Phase 2
Active, not recruiting	`NCT02780310` - Testing Lenvatinib in Patients With Adenoid Cystic Carcinoma	Phase 2
Completed	`NCT04119453` - A Study to Evaluate the Efficacy and Safety of Rivoceranib in Participants With Recurrent or Metastatic Adenoid Cystic Carcinoma (ACC)	Phase 2
Active, not recruiting	`NCT02098538` - Regorafenib in Patients With Progressive, Recurrent/Metastatic Adenoid Cystic Carcinoma	Phase 2
Completed	`NCT01524692` - Study of Dovitinib (TKI258) in Adenoid Cystic Carcinoma	Phase 2
Completed	`NCT01558661` - Axitinib (AG-013736) in Patients With Progressive, Recurrent/Metastatic Adenoid Cystic Carcinoma	Phase 2
Recruiting	`NCT03556228` - Selective TrkA Inhibitor VMD-928 to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma	Phase 1
Not yet recruiting	`NCT06462183` - Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)	Phase 1
Recruiting	`NCT01192087` - Adenoid Cystic Carcinoma, Erbitux, and Particle Therapy	Phase 1/Phase 2
Recruiting	`NCT04209660` - Lenvatinib and Pembrolizumab in People With Advanced Adenoid Cystic Carcinoma and Other Salivary Gland Cancers	Phase 2