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Adenocarcinoma of the Rectum clinical trials

View clinical trials related to Adenocarcinoma of the Rectum.

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NCT ID: NCT05672524 Recruiting - Rectal Cancer Clinical Trials

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

Start date: December 30, 2022
Phase: Phase 2
Study type: Interventional

The study researchers believe that a combination of the drugs trastuzumab and tucatinib, given with standard chemotherapy (capecitabine and oxaliplatin/FOLFOX), may help participants with rectal cancer.

NCT ID: NCT05669430 Recruiting - Clinical trials for Non-small Cell Lung Cancer

A Study of GV20-0251 in Patients With Solid Tumor Malignancies

Start date: March 23, 2023
Phase: Phase 1
Study type: Interventional

This is a Phase 1 study of GV20-0251 being developed for the treatment of participants with advanced solid tumors, who are refractory to approved therapies or other standard of care.

NCT ID: NCT05080673 Recruiting - Clinical trials for Adenocarcinoma of the Rectum

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

FORTE
Start date: October 6, 2021
Phase: N/A
Study type: Interventional

This trial examines colorectal cancer incidence in participants with 1 to 2 non-advanced adenomas randomized to surveillance colonoscopy at 10 years compared to participants randomized to surveillance colonoscopy at 5 and 10 years.

NCT ID: NCT04668872 Recruiting - Colorectal Cancer Clinical Trials

Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation

Start date: December 7, 2020
Phase:
Study type: Observational

The purpose of this study is to study the way radioembolization works by collecting biopsy samples of participants' tumors after the procedure. This research may improve the way that radioembolization is performed, which could help people whose cancer has spread to the liver. The research may also provide information about how tumors respond to radioembolization.

NCT ID: NCT04624555 Recruiting - Clinical trials for Adenocarcinoma of the Rectum

The Utility and Feasibility of Mt-sDNA as a Surveillance Procedure in Colorectal Cancer Survivors

Start date: June 30, 2024
Phase:
Study type: Observational

The purpose of this research study is to determine whether testing of stool for a panel of markers will enable us to detect polyps and cancer compared to standard testing.

NCT ID: NCT04005118 Recruiting - Clinical trials for Adenocarcinoma of the Rectum

Human Intestinal Microbiome and Surgical Outcomes in Patients Undergoing Colorectal Cancer Surgery

Microbiota
Start date: May 28, 2019
Phase:
Study type: Observational

Intro: Recent studies on colorectal cancer surgery have been focusing on the role of intestinal microbiome on surgical outcomes. Standard perioperative cares, like mechanic bowel preparation (MBP), administration of antibiotics (ABT) and surgery-related stress and injury influence the microbiome composition and possibly induce a shift toward a microbiome dysbiotic state, which predisposes to complicated postoperative course. Microbiome composition changes and enhanced virulence factors may increase the risk of postoperative complications, such as anastomotic leakage (AL), surgical site infection (SSI), and postoperative ileus (PI), which are known to impact on patient's overall survival and cancer recurrence. Objective: The primary objective is to investigate if a significant association might exist between the microbiome composition and the occurrence of postoperative complications at 90 days. Methods: 3 different microbiome samples will be taken from all patients. Two fresh fecal samples for detection of LM and fecal water preparation: a) a day before the surgery before MBP and/or ABT (LM1), b) postoperatively after first bowel movement (LM2). One sample will be taken intra-operatively from the stapled resection lines of circular stapler used for forming a colorectal anastomosis, to detect the MAM and to perform immunohistochemistry staining for detection of HACE1 expression. DNA analysis will be performed for all samples. IHC will be performed for detecting HACE1 expression in the tumor and colorectal anastomosis tissues using anti-HACE1 antibodies. . For proliferation assessment, human colon carcinoma cell lines HT29 will be plated in monolayers and scratched with a single scratch. Monolayers will be incubated for 24 hours with fecal water from patients with surgical complications and matched control patients without complications. Descriptive statistics will be performed to describe the study population. This project aim to describe microbiome composition and its impact on postoperative complications.

NCT ID: NCT03303547 Recruiting - Clinical trials for Adenocarcinoma of the Rectum

Concordance of Imaging and Pathology Diagnosis of Extranodal Tumour Deposits

COMET
Start date: October 16, 2017
Phase: N/A
Study type: Interventional

Any patient with a suspected primary adenocarcinoma of the colon, sigmoid or rectum undergoing surgery are eligible. The date of surgery must be known prior to registration. This trial aims to determine if image mapping techniques can improve the concordance between imaging and pathology detection of tumour deposits. Lymph nodes and tumour deposits will be identified on pre-operative scans and mapped by radiologists then shared with pathologists prior to processing the resected specimen. Patients will be managed at their local hospital with standard follow-up. Patients will be followed up for 5 years.

NCT ID: NCT02945566 Recruiting - Clinical trials for Adenocarcinoma of the Rectum

Can we Save the Rectum by Watchful Waiting or TransAnal Surgery Following (Chemo)Radiotherapy Versus Total Mesorectal Excision for Early REctal Cancer?

STAR-TREC
Start date: June 14, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

Bowel cancer is the second most common tumour with 41 000 new cases diagnosed annually in the UK, 447 000 across Europe and 1.36 million worldwide; of which one third are located in the rectum. Standard primary radical Total Mesorectal Excision (TME) surgery is an oncologically effective treatment for early stage rectal cancer. However, resection of a low rectal tumour requires a permanent stoma in approximately 10% of cases while many more patients have a temporary stoma, some of which are not reversed. Radical surgery, which evolved to treat locally advanced, symptomatic tumours, may not be the optimal method of treatment for early screen-detected tumours and an organ preserving strategy may generate significantly less morbidity without substantially compromising oncological outcomes. STAR-TREC is a rolling phase II/III study. Phase II aimed to assess the feasibility of a large, multi-centre randomised trial comparing radical surgery versus two contrasting organ saving treatments followed by selective transanal microsurgery. Phase III will evaluate two contrasting organ preservation strategies in terms of organ preservation rates, toxicity (clinician and patient-reported) and Health-Related Quality of Life (HRQoL).