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The Hypothalamic-Pituitary-Adrenal (HPA) Axis as an Effector System in Weight Regulation

Obesity Clinical Trial

Official title:
Cortisol, Central Obesity, and Insulin Resistance: Long Term Studies in Addison's Patients

Clinical Trial Summary

Replacing glucocorticoid in a dose dependent manner (including doses within the physiological range) to subjects with adrenal insufficiency will increase visceral fat accumulation independently of total fat mass.

Clinical Trial Description

To measure total fat mass by DEXA scan, central (visceral) fat accumulation, insulin sensitivity by FSIVGTT, lipid levels, and adipocyte gene expression in subjects with AI receiving increasing doses of hydrocortisone replacement (15 mg, 25 mg, and 40 mg per day in split doses) for 4-months at a time during ad-lib feeding. ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00688987
Study type Interventional
Source Oregon Health and Science University
Contact
Status Completed
Phase N/A
Start date August 2000
Completion date August 2004
View Details
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