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Addison's Disease clinical trials

View clinical trials related to Addison's Disease.

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NCT ID: NCT05350020 Recruiting - Addison's Disease Clinical Trials

The Effects of Two Brands of Hydrocortisone Injected Intramuscularly Into Deltoid and Thigh Muscles

Start date: March 14, 2022
Phase: Phase 4
Study type: Interventional

The study will be looking at the cortisol profiles of hypocortisolaemic patients following 100mg injections of two hydrocortisone preparations (Solu-Cortef® & Hydrocortisone 100mg/ml). The investigators plan to use two methods of intramuscular injection to administer the preparations, one using a 1inch orange needle into the deltoid muscle and the other using a 1.25inch blue needle into the thigh muscle.

NCT ID: NCT04252001 Not yet recruiting - Clinical trials for Growth Hormone Deficiency

Growing up With the Young Endocrine Support System (YESS!)

YESS
Start date: December 1, 2024
Phase: N/A
Study type: Interventional

Transition from paediatric to adult endocrinology is a challenge for adolescents, families and doctors. Up to 25% of young adults with chronic endocrine disorders are lost to follow-up ('drop-out') once the young adult moves out of paediatric care. Non-attendance and sub-optimal medical self-management can lead to serious and expensive medical complications. In a pilot study, adolescents suggested the use of e-technology to become more involved in the transition process. The investigators have designed and developed the YESS! game, a tool to help improve medical self-management in adolescents with chronic endocrine disorders. The hypothesis is that adolescents playing the YESS! game will show a larger increase in self-management score during the first year of transition and will have a lower drop-out rate at the adult endocrine outpatient clinic (OPC), compared to adolescents who do not play the game.

NCT ID: NCT01657123 Not yet recruiting - Addison's Disease Clinical Trials

Exercise Capacity and Recovery in Addison's Disease

Start date: January 2013
Phase: N/A
Study type: Interventional

Exposure to stress alters the activity of the adrenomedullary, adrenocortical and sympathetic nervous system, depending on the type and intensity of the stressor. Physical exercise represents a stress condition influencing many systems in the body. Given a workload of at least 70-85% of Vo2max, exercise is a potent stimulus of the hypothalamic-pituitary-adrenal (HPA)-axis. The increased endogenous cortisol secretion results in important metabolic and cardiovascular effects to maintain cellular and organ homeostasis. Patients with Addison's disease are not able to meet the increased demand of adrenal steroids in case of physical exercise, which may result in an impaired exercise capacity and a prolonged post-exercise recovery. We hypothesize that a hydrocortisone stress dose increases exercise capacity and improves post-exercise recovery in patients with Addison's disease.

NCT ID: NCT01452893 Completed - Clinical trials for Adrenal Insufficiency

Counterregulatory Hormone Production in Adrenal Insufficiency and Diabetes Type I

CANDI
Start date: March 2011
Phase: N/A
Study type: Observational

Patients with adrenal insufficiency also exhibit an adrenomedullary dysfunction. Furthermore, patients who suffer from both, adrenal insufficiency and type I diabetes more frequently report hypoglycemia, particularly after strenuous activities. The study investigates the counter regulatory hormonal response to physical stress and the impact on cognitive function in subjects with and without Addison's disease, type I diabetes and healthy subjects.

NCT ID: NCT01063569 Completed - Addison's Disease Clinical Trials

Glucocorticoid Treatment in Addison's Disease

Start date: February 2010
Phase: Phase 2/Phase 3
Study type: Interventional

Addison's disease is a rare condition which in most cases is caused by autoimmune destruction of the adrenals, leading to deficiency of cortisol, aldosterone and adrenal androgens. Unrecognized the disease is life threatening, but with proper treatment patients can live near normal lives. The conventional glucocorticoid replacement therapy renders the cortisol levels unphysiological, which may cause symptoms and long-term complications. Glucocorticoid replacement therapy is technically feasible by continuous subcutaneous hydrocortisone infusion (CSHI), and can mimic the normal diurnal cortisol rhythm. This study aims to further evaluate CSHI treatment in terms of metabolic effects, effects on health-related quality-of-life and sleep in an 8 months randomised open label clinical trial with crossover design.

NCT ID: NCT00688987 Completed - Obesity Clinical Trials

The Hypothalamic-Pituitary-Adrenal (HPA) Axis as an Effector System in Weight Regulation

Start date: August 2000
Phase: N/A
Study type: Interventional

Replacing glucocorticoid in a dose dependent manner (including doses within the physiological range) to subjects with adrenal insufficiency will increase visceral fat accumulation independently of total fat mass.

NCT ID: NCT00444119 Completed - Clinical trials for Adrenal Insufficiency

Survey in Patients With Chronic Adrenal Insufficiency in Germany

Start date: May 2004
Phase: N/A
Study type: Observational

The purpose of this survey is to assess patients with chronic primary or secondary adrenal failure regarding subjective health status, incidence and causes of adrenal crisis, hormone replacement regimens and concomitant endocrine or non endocrine disease.

NCT ID: NCT00004313 Completed - Addison's Disease Clinical Trials

Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency

Start date: August 1995
Phase: Phase 3
Study type: Interventional

OBJECTIVES: I. Determine the efficacy of dehydroepiandrosterone (DHEA), an androgen replacement hormone, for patients with primary adrenal insufficiency (Addison's disease).