Acute Uncomplicated Bacterial Cystitis Clinical Trial
Official title:
Epidemiology of Acute Bacterial Uncomplicated Cystitis in General Practice: Description and Prediction by Urine Dipstick Test
Acute uncomplicated bacterial cystitis is common in general practice. Cystitis is at the
second raw of antibiotic treatment indications. It has been now recommended not to perform
any urine culture for more than 20 years; hence, the bacterial epidemiology of acute
uncomplicated cystitis is surprisingly relatively unknown. The available bacteriological
data mainly describe the epidemiology of complicated urinary tract infections or upper
urinary tract infections, but the causative bacteria and the resistance rates might differ
from those of uncomplicated cystitis. As an example, it is unknown to what extent
Staphylococcus saprophyticus is the causative agent of uncomplicated cystitis.
Moreover, the urine dipstick test have been evaluated in laboratories. But their
interpretation in current practice might not be so easy: in particular, the nitrite
detection depends on the bacterial concentration. The nitrite detection, produced in
enterobacteriaceae related infections might have therapeutical consequences:
trométamol-fosfomycine is almost constantly active on enterobacteriaceae, but ineffective on
staphylococci. Knowing the increasing prevalence of fluoroquinolone-resistant
enterobacteriaceae, the use of fosfomycin in nitrite positive uncomplicated cystitis might
preserve the susceptibility of fluoroquinolones during pyelonephritis.
This study will describe:
- the bacterial epidemiology of acute uncomplicated cystitis in general practice,
- the correlation in between urine dipstick and urine culture in general practice,
- the prediction of enterobacterial infection by the nitrite detection, AND
- the antibiotics prescribed by the practitioners for uncomplicated acute cystitis.
n/a
Observational Model: Case-Only, Time Perspective: Prospective