Acute Pyelonephritis Clinical Trial
Official title:
Phase III, Randomized, Double-Blind, Study Evaluating Efficacy/Safety/Tolerability of Meropenem-Vaborbactam Compared to Piperacillin/Tazobactam in Adult Patients With Complicated Urinary Tract Infections, Including Acute Pyelonephritis
Meropenem-vaborbactam is being compared to piperacillin-tazobactam in the treatment of adults with complicated urinary tract infection (cUTI) or acute pyelonephritis (AP).
In the current era of increased resistance to extended spectrum cephalosporins, carbapenem
antimicrobial agents are frequently the antibiotics of "last defense" for the most resistant
pathogens in serious infections, including those found in cUTIs. The recent dissemination of
serine carbapenemases in Enterobacteriaceae in many hospitals worldwide now poses a
considerable threat to the carbapenems and other members of the beta-lactam class of
antimicrobial agents.
Rempex is developing meropenem-vaborbactam administered as a fixed combination by intravenous
infusion to treat serious Gram-negative infections such as cUTIs, including those infections
caused by bacteria resistant to currently available carbapenems.
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