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Acute Poisoning clinical trials

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NCT ID: NCT06447584 Recruiting - Acute Poisoning Clinical Trials

Clinical Spectrum and Outcome of Poisoning in Children Admitted to the Pediatric Emergency and Intensive Care Units at Sohag University Hospital

Start date: June 1, 2024
Phase:
Study type: Observational

Acute poisoning is a major health problem that leads to emergent hospital admission.It has become the main factor that harms children and leads to disability and death of children. Also, it is still a serious issue in developing countries where it represents a common cause of emergency department presentation and admission. Acute poisoning can be divided into two categories (accidental and intentional),accidental poisoning is common in children under five years, whereas intentional poisoning is more common in adolescents, WHO estimated that, in 2016, accidental poisoning caused 106,683 deaths and the loss of 6.3 million years of healthy life. A study in Romania showed that intentional poisoning is the most common cause of poisoning among teenagers. Females are more vulnerable to suicidal or intentional poisoning than males. Medications, alcohol, and substance abuse are common poisoning agents among teenagers , another study at tertiary Indian hospital, pesticides, pharmaceutical drugs, and household products were the most common types of acute poisoning. Pesticides were reported as a cause of intentional and accidental poisoning. In agricultural areas, people were poisoned accidentally by pesticides that may be used for suicidal attempts because of their availability. Pharmaceutical drugs are also used for intentional poisoning due to the availability of street drugs and over-the-counter medications. Accidental poisoning by household products were observed in children and the most common products are hydrocarbon and naphthalene In Egypt acute poisoning represents a significant proportion of emergency visits of children and young people. This labors a burden on healthcare, society and economy and thus, it drain-s resources and multiplies workload . In fact, it is a preventable cause of morbidity and mortality. Children poisoning is a result of multiple risk factors including social, demographic, and industrial factors. Insufficient public awareness, easy accessibility to poison, negligence of caregivers, technological and industrial advances and even the nature of the environment are of the main causes.

NCT ID: NCT06413589 Completed - Acute Poisoning Clinical Trials

Efficacy of SMOF Lipid in the Management of Acute Poisoning With Clozapine

Start date: January 1, 2022
Phase: Phase 2
Study type: Interventional

The goal of the current study was to evaluate whether SMOF lipid administration could be used as an adjuvant therapy to treat acute, moderate-to-severe clozapine poisoning.

NCT ID: NCT06316362 Completed - Acute Poisoning Clinical Trials

Efficacy of SMOF Lipid in the Management of Acute Poisoning With Carbamazepine

Start date: January 1, 2022
Phase: Phase 2
Study type: Interventional

The goal of the current study was to evaluate whether SMOF lipid administration could be used as an adjuvant therapy to treat acute, moderate-to-severe carbamazepine poisoning.

NCT ID: NCT05185570 Not yet recruiting - Acute Poisoning Clinical Trials

Prognosis of Elderly Patients With Acute Poisoning.

Start date: January 2022
Phase:
Study type: Observational

Acute poisoning is a major public health problem all over the world, it causes significant mortality and morbidity. It primarily involves younger populations, with less than 3% of the affected cases being in people aged 60 years or older in most studies. More than half of the intoxication events in the elderly over 65 years old were accidental.

NCT ID: NCT05148611 Not yet recruiting - Acute Poisoning Clinical Trials

Application Registration Study of ILE in Patients With Acute Poisoning

ILE
Start date: November 30, 2021
Phase:
Study type: Observational [Patient Registry]

In this study, the investigators aimed to study the effect of ILE in the treatment of acute fat-soluble substance poisoning,to further clarify the relevant mechanism of ILE in the treatment of fat-soluble drug poisoning,to standardize the relevant procedures of ILE detoxification treatment and further explore the adverse reactions and coping strategies of ILE treatment.

NCT ID: NCT00780078 Completed - Heart Failure Clinical Trials

Clinical Evaluation of Swallowing Disorders as a Predictor of Extubation Failure

EVAKIN
Start date: October 2008
Phase: N/A
Study type: Observational

Patients with failed extubation stay significantly longer in an intensive care unit (ICU) and have a higher mortality rate, than those intubated successfully. Reintubation is associated with life-threatening complications and a poor prognosis. Functional respiratory tests are frequently used as weaning parameters, however, they are not accurate enough to predict extubation failure. The incidence of swallowing dysfunction is underestimated, mainly among patients whose intubation lasts longer than 48 h.We previously observed that the assessment of the swallowing function and oropharyngeal motricity, conducted by the physiotherapist before extubation could be helpful for making decisions to extubate patients intubated for over 6 days. The objective of this study is to validate a scale previously devised and used for physiotherapist bedside evaluation of the swallowing function and oropharyngeal motricity, among patients intubated for over 6 days, to determine whether this scale is a good predictor of airway secretion-related extubation failure.Expected results : to validate a scale previously devised called " physiotherapist evaluation of the swallowing function and oropharyngeal motricity before extubation" by the mean of a multicentric study. In our hypothesis the clinical parameters studied could be predictive of extubation failure. Then, this evaluation could help the medical decision in the choice of the good time for extubation. The final objective is to lower the mortality related to extubation failure.